Chronic impact of tetracycline on the biodegradation of an organic substrate mixture under anaerobic conditions
The study evaluates the chronic impact of the antibiotic tetracycline on the biodegradation of organic substrate under anaerobic conditions. The experiments involved an anaerobic sequencing batch reactor fed with a synthetic substrate mixture including glucose, starch and volatile fatty acids, and operated in a sequence of different phases with gradually increasing tetracycline doses of 1.65–8.5 mg/L, for more than five months. Tetracycline exerted a terminal/lethal effect at 8.5 mg/L on the microbial community under anaerobic conditions, which caused the inhibition of substrate/COD utilization and biogas generation and leading to a total collapse of the reactor. The microbial activity could not be recovered and re-started within a period of more than 10 days, even after stopping tetracycline dosing. At lower doses, substrate utilization was not affected but a reduction of 10–20% was observed in the biogas/methane generation, suggesting that substrate utilization of tetracycline to the biomass was limiting their bioavailability. During the experiments, tetracycline was partially removed either through biodegradation or conversion into its by-products. The adverse long-term impact was quite variable for fermenting heterotrophic and methanogenic fractions of the microbial community based on changes inflicted on the composition of remaining/residual organic substrate.
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Format: | artículo biblioteca |
Language: | English |
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Elsevier
2013
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Subjects: | Tetracycline, Chronic inhibition, Anaerobic biodegradation, Methanogenesis, COD removal, |
Online Access: | http://hdl.handle.net/10261/77982 |
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dig-idaea-es-10261-779822017-06-30T07:28:17Z Chronic impact of tetracycline on the biodegradation of an organic substrate mixture under anaerobic conditions Cetecioglu, Z. Ince, B. Gros, Meritxell Rodriguez-Mozaz, S. Barceló, Damià Orhon, D. Ince, O. Tetracycline Chronic inhibition Anaerobic biodegradation Methanogenesis COD removal The study evaluates the chronic impact of the antibiotic tetracycline on the biodegradation of organic substrate under anaerobic conditions. The experiments involved an anaerobic sequencing batch reactor fed with a synthetic substrate mixture including glucose, starch and volatile fatty acids, and operated in a sequence of different phases with gradually increasing tetracycline doses of 1.65–8.5 mg/L, for more than five months. Tetracycline exerted a terminal/lethal effect at 8.5 mg/L on the microbial community under anaerobic conditions, which caused the inhibition of substrate/COD utilization and biogas generation and leading to a total collapse of the reactor. The microbial activity could not be recovered and re-started within a period of more than 10 days, even after stopping tetracycline dosing. At lower doses, substrate utilization was not affected but a reduction of 10–20% was observed in the biogas/methane generation, suggesting that substrate utilization of tetracycline to the biomass was limiting their bioavailability. During the experiments, tetracycline was partially removed either through biodegradation or conversion into its by-products. The adverse long-term impact was quite variable for fermenting heterotrophic and methanogenic fractions of the microbial community based on changes inflicted on the composition of remaining/residual organic substrate. This study was funded by The Turkish Academy of Sciences (TUBA). It was also this work was partly supported by the Generalitat de Catalunya (Consolidated Research Group: Water and Soil Quality Unit 2009-SGR-965). Peer reviewed 2013-06-12T07:59:04Z 2013-06-12T07:59:04Z 2013 artículo http://purl.org/coar/resource_type/c_6501 Water Research 47 (9) : 2959–2969 (2013) 0043-1354 http://hdl.handle.net/10261/77982 10.1016/j.watres.2013.02.053 1879-2448 en http://dx.doi.org/10.1016/j.watres.2013.02.053 open Elsevier |
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Tetracycline Chronic inhibition Anaerobic biodegradation Methanogenesis COD removal Tetracycline Chronic inhibition Anaerobic biodegradation Methanogenesis COD removal |
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Tetracycline Chronic inhibition Anaerobic biodegradation Methanogenesis COD removal Tetracycline Chronic inhibition Anaerobic biodegradation Methanogenesis COD removal Cetecioglu, Z. Ince, B. Gros, Meritxell Rodriguez-Mozaz, S. Barceló, Damià Orhon, D. Ince, O. Chronic impact of tetracycline on the biodegradation of an organic substrate mixture under anaerobic conditions |
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The study evaluates the chronic impact of the antibiotic tetracycline on the biodegradation of organic substrate under anaerobic conditions. The experiments involved an anaerobic sequencing batch reactor fed with a synthetic substrate mixture including glucose, starch and volatile fatty acids, and operated in a sequence of different phases with gradually increasing tetracycline doses of 1.65–8.5 mg/L, for more than five months. Tetracycline exerted a terminal/lethal effect at 8.5 mg/L on the microbial community under anaerobic conditions, which caused the inhibition of substrate/COD utilization and biogas generation and leading to a total collapse of the reactor. The microbial activity could not be recovered and re-started within a period of more than 10 days, even after stopping tetracycline dosing. At lower doses, substrate utilization was not affected but a reduction of 10–20% was observed in the biogas/methane generation, suggesting that substrate utilization of tetracycline to the biomass was limiting their bioavailability. During the experiments, tetracycline was partially removed either through biodegradation or conversion into its by-products. The adverse long-term impact was quite variable for fermenting heterotrophic and methanogenic fractions of the microbial community based on changes inflicted on the composition of remaining/residual organic substrate. |
format |
artículo |
topic_facet |
Tetracycline Chronic inhibition Anaerobic biodegradation Methanogenesis COD removal |
author |
Cetecioglu, Z. Ince, B. Gros, Meritxell Rodriguez-Mozaz, S. Barceló, Damià Orhon, D. Ince, O. |
author_facet |
Cetecioglu, Z. Ince, B. Gros, Meritxell Rodriguez-Mozaz, S. Barceló, Damià Orhon, D. Ince, O. |
author_sort |
Cetecioglu, Z. |
title |
Chronic impact of tetracycline on the biodegradation of an organic substrate mixture under anaerobic conditions |
title_short |
Chronic impact of tetracycline on the biodegradation of an organic substrate mixture under anaerobic conditions |
title_full |
Chronic impact of tetracycline on the biodegradation of an organic substrate mixture under anaerobic conditions |
title_fullStr |
Chronic impact of tetracycline on the biodegradation of an organic substrate mixture under anaerobic conditions |
title_full_unstemmed |
Chronic impact of tetracycline on the biodegradation of an organic substrate mixture under anaerobic conditions |
title_sort |
chronic impact of tetracycline on the biodegradation of an organic substrate mixture under anaerobic conditions |
publisher |
Elsevier |
publishDate |
2013 |
url |
http://hdl.handle.net/10261/77982 |
work_keys_str_mv |
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1777669242193182720 |