Effects of Indoor Dust Exposure on Lung Cells: Association of Chemical Composition with Phenotypic and Lipid Changes in a 3D Lung Cancer Cell Model
Indoor dust is a key contributor to the global human exposome in urban areas since the population develops most of its activities in private and public buildings. To gain insight into the health risks associated with this chronic exposure, it is necessary to characterize the chemical composition of dust and understand its biological impacts using reliable physiological models. The present study investigated the biological effects of chemically characterized indoor dust extracts using three-dimensional (3D) lung cancer cell cultures combining phenotypic and lipidomic analyses. Apart from the assessment of cell viability, reactive oxygen species (ROS) induction, and interleukin-8 release, lipidomics was applied to capture the main lipid changes induced as a cellular response to the extracted dust compounds. The application of chemometric tools enabled the finding of associations between chemical compounds present in dust and lipidic and phenotypic profiles in the cells. This study contributes to a better understanding of the toxicity mechanisms associated with exposure to chemical pollutants present in indoor dust.
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American Chemical Society
2023-12-12
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Subjects: | Lung cells, 3D cultures, Air pollutants, Chemometrics, Data fusion, Indoor air, Lipidomics, Organophosphate esters, http://metadata.un.org/sdg/11, http://metadata.un.org/sdg/12, Make cities and human settlements inclusive, safe, resilient and sustainable, Responsible Consumption and Production, |
Online Access: | http://hdl.handle.net/10261/341133 http://dx.doi.org/10.13039/501100004837 https://api.elsevier.com/content/abstract/scopus_id/85179602246 |
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dig-idaea-es-10261-3411332024-05-16T20:37:35Z Effects of Indoor Dust Exposure on Lung Cells: Association of Chemical Composition with Phenotypic and Lipid Changes in a 3D Lung Cancer Cell Model Pyambri, Maryam Lacorte Bruguera, Silvia Jaumot, Joaquim Bedia, Carmen Ministerio de Ciencia e Innovación (España) 0000-0003-4584-5843 Lung cells 3D cultures Air pollutants Chemometrics Data fusion Indoor air Lipidomics Organophosphate esters http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/12 Make cities and human settlements inclusive, safe, resilient and sustainable Responsible Consumption and Production Indoor dust is a key contributor to the global human exposome in urban areas since the population develops most of its activities in private and public buildings. To gain insight into the health risks associated with this chronic exposure, it is necessary to characterize the chemical composition of dust and understand its biological impacts using reliable physiological models. The present study investigated the biological effects of chemically characterized indoor dust extracts using three-dimensional (3D) lung cancer cell cultures combining phenotypic and lipidomic analyses. Apart from the assessment of cell viability, reactive oxygen species (ROS) induction, and interleukin-8 release, lipidomics was applied to capture the main lipid changes induced as a cellular response to the extracted dust compounds. The application of chemometric tools enabled the finding of associations between chemical compounds present in dust and lipidic and phenotypic profiles in the cells. This study contributes to a better understanding of the toxicity mechanisms associated with exposure to chemical pollutants present in indoor dust. This research was funded by MCIN/AEI/10.13039/501100011033 (Severo Ochoa Projects CEX2018-000794-S and PID2019-105732GC-C21). Peer reviewed 2023-12-21T10:16:08Z 2023-12-21T10:16:08Z 2023-12-12 artículo http://purl.org/coar/resource_type/c_6501 Environmental Science and Technology 57 (49): 20532–20541 (2023) 0013936X http://hdl.handle.net/10261/341133 10.1021/acs.est.3c07573 http://dx.doi.org/10.13039/501100004837 38035630 2-s2.0-85179602246 https://api.elsevier.com/content/abstract/scopus_id/85179602246 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MCIN/AEI/10.13039/501100011033 Environmental science & technology Publisher's version https://doi.org/10.1021/acs.est.3c07573 Sí open American Chemical Society |
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Lung cells 3D cultures Air pollutants Chemometrics Data fusion Indoor air Lipidomics Organophosphate esters http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/12 Make cities and human settlements inclusive, safe, resilient and sustainable Responsible Consumption and Production Lung cells 3D cultures Air pollutants Chemometrics Data fusion Indoor air Lipidomics Organophosphate esters http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/12 Make cities and human settlements inclusive, safe, resilient and sustainable Responsible Consumption and Production |
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Lung cells 3D cultures Air pollutants Chemometrics Data fusion Indoor air Lipidomics Organophosphate esters http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/12 Make cities and human settlements inclusive, safe, resilient and sustainable Responsible Consumption and Production Lung cells 3D cultures Air pollutants Chemometrics Data fusion Indoor air Lipidomics Organophosphate esters http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/12 Make cities and human settlements inclusive, safe, resilient and sustainable Responsible Consumption and Production Pyambri, Maryam Lacorte Bruguera, Silvia Jaumot, Joaquim Bedia, Carmen Effects of Indoor Dust Exposure on Lung Cells: Association of Chemical Composition with Phenotypic and Lipid Changes in a 3D Lung Cancer Cell Model |
description |
Indoor dust is a key contributor to the global human exposome in urban areas since the population develops most of its activities in private and public buildings. To gain insight into the health risks associated with this chronic exposure, it is necessary to characterize the chemical composition of dust and understand its biological impacts using reliable physiological models. The present study investigated the biological effects of chemically characterized indoor dust extracts using three-dimensional (3D) lung cancer cell cultures combining phenotypic and lipidomic analyses. Apart from the assessment of cell viability, reactive oxygen species (ROS) induction, and interleukin-8 release, lipidomics was applied to capture the main lipid changes induced as a cellular response to the extracted dust compounds. The application of chemometric tools enabled the finding of associations between chemical compounds present in dust and lipidic and phenotypic profiles in the cells. This study contributes to a better understanding of the toxicity mechanisms associated with exposure to chemical pollutants present in indoor dust. |
author2 |
Ministerio de Ciencia e Innovación (España) |
author_facet |
Ministerio de Ciencia e Innovación (España) Pyambri, Maryam Lacorte Bruguera, Silvia Jaumot, Joaquim Bedia, Carmen |
format |
artículo |
topic_facet |
Lung cells 3D cultures Air pollutants Chemometrics Data fusion Indoor air Lipidomics Organophosphate esters http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/12 Make cities and human settlements inclusive, safe, resilient and sustainable Responsible Consumption and Production |
author |
Pyambri, Maryam Lacorte Bruguera, Silvia Jaumot, Joaquim Bedia, Carmen |
author_sort |
Pyambri, Maryam |
title |
Effects of Indoor Dust Exposure on Lung Cells: Association of Chemical Composition with Phenotypic and Lipid Changes in a 3D Lung Cancer Cell Model |
title_short |
Effects of Indoor Dust Exposure on Lung Cells: Association of Chemical Composition with Phenotypic and Lipid Changes in a 3D Lung Cancer Cell Model |
title_full |
Effects of Indoor Dust Exposure on Lung Cells: Association of Chemical Composition with Phenotypic and Lipid Changes in a 3D Lung Cancer Cell Model |
title_fullStr |
Effects of Indoor Dust Exposure on Lung Cells: Association of Chemical Composition with Phenotypic and Lipid Changes in a 3D Lung Cancer Cell Model |
title_full_unstemmed |
Effects of Indoor Dust Exposure on Lung Cells: Association of Chemical Composition with Phenotypic and Lipid Changes in a 3D Lung Cancer Cell Model |
title_sort |
effects of indoor dust exposure on lung cells: association of chemical composition with phenotypic and lipid changes in a 3d lung cancer cell model |
publisher |
American Chemical Society |
publishDate |
2023-12-12 |
url |
http://hdl.handle.net/10261/341133 http://dx.doi.org/10.13039/501100004837 https://api.elsevier.com/content/abstract/scopus_id/85179602246 |
work_keys_str_mv |
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_version_ |
1802820424761868288 |