Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome
The aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteome, and the metabolome. The chemical exposome, deeply intertwined with the metabolome, includes all small molecules originating from diet as well as pharmaceuticals, personal care and consumer products, or pollutants in air and water. The set of techniques to interrogate these exposures, primarily mass spectrometry and nuclear magnetic resonance spectroscopy, are also extensively used in metabolomics. Recent advances in untargeted metabolomics using high resolution mass spectrometry have paved the way for the development of methods able to provide in depth characterisation of both the internal chemical exposome and the endogenous metabolome simultaneously. Herein we review the available tools, databases, and workflows currently available for such work, and discuss how these can bridge the gap between the study of the metabolome and the exposome.
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Elsevier
2023-12-11
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Subjects: | Metabolomics, Chemical exposome, Exposomics, HRMS, Mass spectrometry, http://metadata.un.org/sdg/3, Ensure healthy lives and promote well-being for all at all ages, |
Online Access: | http://hdl.handle.net/10261/341127 http://dx.doi.org/10.13039/501100000780 https://api.elsevier.com/content/abstract/scopus_id/85179607572 |
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dig-idaea-es-10261-3411272024-05-17T20:40:37Z Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome Balcells, Cristina Xu, Yitao Gil-Solsona, Rubén Maitre, Léa Gago-Ferrero, Pablo Keun, Hector C. European Commission 0000-0002-7927-5538 Metabolomics Chemical exposome Exposomics HRMS Mass spectrometry http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages The aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteome, and the metabolome. The chemical exposome, deeply intertwined with the metabolome, includes all small molecules originating from diet as well as pharmaceuticals, personal care and consumer products, or pollutants in air and water. The set of techniques to interrogate these exposures, primarily mass spectrometry and nuclear magnetic resonance spectroscopy, are also extensively used in metabolomics. Recent advances in untargeted metabolomics using high resolution mass spectrometry have paved the way for the development of methods able to provide in depth characterisation of both the internal chemical exposome and the endogenous metabolome simultaneously. Herein we review the available tools, databases, and workflows currently available for such work, and discuss how these can bridge the gap between the study of the metabolome and the exposome. CB, LM and HCK received funding from European Union's Horizon 2020 research and innovation programme under grant agreement no. 874583 [ATHLETE]. YX is supported by the President's PhD Scholarship from Imperial College London. Peer reviewed 2023-12-21T10:03:55Z 2023-12-21T10:03:55Z 2023-12-11 artículo http://purl.org/coar/resource_type/c_6501 Current Opinion in Chemical Biology 78: 102407 (2024) 13675931 http://hdl.handle.net/10261/341127 10.1016/j.cbpa.2023.102407 http://dx.doi.org/10.13039/501100000780 38086287 2-s2.0-85179607572 https://api.elsevier.com/content/abstract/scopus_id/85179607572 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/874583 Current opinion in chemical biology Publisher's version https://doi.org/10.1016/j.cbpa.2023.102407 Sí open Elsevier |
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Metabolomics Chemical exposome Exposomics HRMS Mass spectrometry http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages Metabolomics Chemical exposome Exposomics HRMS Mass spectrometry http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages |
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Metabolomics Chemical exposome Exposomics HRMS Mass spectrometry http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages Metabolomics Chemical exposome Exposomics HRMS Mass spectrometry http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages Balcells, Cristina Xu, Yitao Gil-Solsona, Rubén Maitre, Léa Gago-Ferrero, Pablo Keun, Hector C. Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome |
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The aetiology of every human disease lies in a combination of genetic and environmental factors, each contributing in varying proportions. While genomics investigates the former, a comparable holistic paradigm was proposed for environmental exposures in 2005, marking the onset of exposome research. Since then, the exposome definition has broadened to include a wide array of physical, chemical, and psychosocial factors that interact with the human body and potentially alter the epigenome, the transcriptome, the proteome, and the metabolome. The chemical exposome, deeply intertwined with the metabolome, includes all small molecules originating from diet as well as pharmaceuticals, personal care and consumer products, or pollutants in air and water. The set of techniques to interrogate these exposures, primarily mass spectrometry and nuclear magnetic resonance spectroscopy, are also extensively used in metabolomics. Recent advances in untargeted metabolomics using high resolution mass spectrometry have paved the way for the development of methods able to provide in depth characterisation of both the internal chemical exposome and the endogenous metabolome simultaneously. Herein we review the available tools, databases, and workflows currently available for such work, and discuss how these can bridge the gap between the study of the metabolome and the exposome. |
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European Commission |
author_facet |
European Commission Balcells, Cristina Xu, Yitao Gil-Solsona, Rubén Maitre, Léa Gago-Ferrero, Pablo Keun, Hector C. |
format |
artículo |
topic_facet |
Metabolomics Chemical exposome Exposomics HRMS Mass spectrometry http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages |
author |
Balcells, Cristina Xu, Yitao Gil-Solsona, Rubén Maitre, Léa Gago-Ferrero, Pablo Keun, Hector C. |
author_sort |
Balcells, Cristina |
title |
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome |
title_short |
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome |
title_full |
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome |
title_fullStr |
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome |
title_full_unstemmed |
Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome |
title_sort |
blurred lines: crossing the boundaries between the chemical exposome and the metabolome |
publisher |
Elsevier |
publishDate |
2023-12-11 |
url |
http://hdl.handle.net/10261/341127 http://dx.doi.org/10.13039/501100000780 https://api.elsevier.com/content/abstract/scopus_id/85179607572 |
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