Neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the Mojana region, Colombia
The present study aims to explore the neuropsychological performance and exposure to mercury (Hg) and arsenic (As) in Colombian children and adolescents considering biomarkers in hair and blood. The total sample consisted of 70 participants from the Mojana region, Colombia. A neuropsychological evaluation protocol was used, consisting of 11 internationally recognized tests, with evidence of national validation and use for measurement in neurotoxicology contexts. A 57.1% of the sample presented levels above the reference value according to the USEPA, the WHO, and the ATSDR for total mercury in hair (HgH), blood mercury (HgB), and/or blood arsenic (AsB). The mean values reported for HgH were 1.76 ± 3.1 μg/g (95% CI 1.02-2.50) with ranges between 0.23 and 17.20; for HgB: 4.11 ± 5.93 μg/l (CI 2.69-5.52), ranging between 0.25 and 25.80, and for AsB: 1.96 ± 2.73 (CI 1.31-2.61) ranging between 0.50 and 15.50. In the comparison of groups in relation to the level of exposure, a significant difference was found (p < 0.05) for the subtest The Boston Naming Test (BNT). Correlation analyses found, on the one hand, significant negative relationships in tests integrated within the verbal (CVB) and executive function (EF) components as well as evidence of positive relationships in the manifestation of errors in their performance with the levels of Hg and/or As transformed by biomarker (Log10). In the linear regression analyses it was found that for each increase in the concentration of HgH, HgB, and AsB it is estimated that, both for the models with and without data adjustment, there is a loss of scores in integrated measures within the CVB and EF for the transformed levels of HgH, HgB, and AsB; and an increase in the reported errors in their processing within these functions. According to these results, exposure to mercury and/or arsenic is related with performance in verbal neuropsychological skills and executive functioning.
Main Authors: | , , , , |
---|---|
Other Authors: | |
Format: | artículo biblioteca |
Language: | English |
Published: |
2022-10-18
|
Subjects: | Neuropsychological performance, Adolescents, Arsenic, Boston naming test, Children, Mercury, http://metadata.un.org/sdg/3, http://metadata.un.org/sdg/4, Ensure healthy lives and promote well-being for all at all ages, Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all, |
Online Access: | http://hdl.handle.net/10261/283799 https://api.elsevier.com/content/abstract/scopus_id/85141307363 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-idaea-es-10261-283799 |
---|---|
record_format |
koha |
spelling |
dig-idaea-es-10261-2837992024-05-14T20:43:42Z Neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the Mojana region, Colombia De la Ossa, César Argumedos Ramírez-Giraldo, Andrés Fernando Arroyo-Alvis, Katy Marrugo-Negrete, José Díez, Sergi 0000-0002-8664-2690 0000-0002-4709-9891 0000-0003-3171-0702 0000-0002-9870-2179 Neuropsychological performance Adolescents Arsenic Boston naming test Children Mercury http://metadata.un.org/sdg/3 http://metadata.un.org/sdg/4 Ensure healthy lives and promote well-being for all at all ages Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all The present study aims to explore the neuropsychological performance and exposure to mercury (Hg) and arsenic (As) in Colombian children and adolescents considering biomarkers in hair and blood. The total sample consisted of 70 participants from the Mojana region, Colombia. A neuropsychological evaluation protocol was used, consisting of 11 internationally recognized tests, with evidence of national validation and use for measurement in neurotoxicology contexts. A 57.1% of the sample presented levels above the reference value according to the USEPA, the WHO, and the ATSDR for total mercury in hair (HgH), blood mercury (HgB), and/or blood arsenic (AsB). The mean values reported for HgH were 1.76 ± 3.1 μg/g (95% CI 1.02-2.50) with ranges between 0.23 and 17.20; for HgB: 4.11 ± 5.93 μg/l (CI 2.69-5.52), ranging between 0.25 and 25.80, and for AsB: 1.96 ± 2.73 (CI 1.31-2.61) ranging between 0.50 and 15.50. In the comparison of groups in relation to the level of exposure, a significant difference was found (p < 0.05) for the subtest The Boston Naming Test (BNT). Correlation analyses found, on the one hand, significant negative relationships in tests integrated within the verbal (CVB) and executive function (EF) components as well as evidence of positive relationships in the manifestation of errors in their performance with the levels of Hg and/or As transformed by biomarker (Log10). In the linear regression analyses it was found that for each increase in the concentration of HgH, HgB, and AsB it is estimated that, both for the models with and without data adjustment, there is a loss of scores in integrated measures within the CVB and EF for the transformed levels of HgH, HgB, and AsB; and an increase in the reported errors in their processing within these functions. According to these results, exposure to mercury and/or arsenic is related with performance in verbal neuropsychological skills and executive functioning. The authors wish to thank the Ministry of Science of Colombia (Minciencias) for funding the internship grant under the “Young Researchers and Innovators” program (Call 775) and to the research groups Human Dimensions (Corporación Universitaria del Caribe-CECAR, Colombia) and Water, Applied and Environmental Chemistry (University of Córdoba, Colombia) who made possible the realization of this study. The authors would also like to acknowledge the Spanish National Research Council (CSIC) through project iCOOP+2018-COOPB20362 and the CYTED (Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo), for financing the MercuRed Network (420RT0007). Peer reviewed 2022-11-25T09:50:37Z 2022-11-25T09:50:37Z 2022-10-18 artículo http://purl.org/coar/resource_type/c_6501 00139351 http://hdl.handle.net/10261/283799 10.1016/j.envres.2022.114467 36265603 2-s2.0-85141307363 https://api.elsevier.com/content/abstract/scopus_id/85141307363 en Environmental research Publisher's version https://doi.org/10.1016/j.envres.2022.114467 Sí open |
institution |
IDAEA ES |
collection |
DSpace |
country |
España |
countrycode |
ES |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-idaea-es |
tag |
biblioteca |
region |
Europa del Sur |
libraryname |
Biblioteca del IDAEA España |
language |
English |
topic |
Neuropsychological performance Adolescents Arsenic Boston naming test Children Mercury http://metadata.un.org/sdg/3 http://metadata.un.org/sdg/4 Ensure healthy lives and promote well-being for all at all ages Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all Neuropsychological performance Adolescents Arsenic Boston naming test Children Mercury http://metadata.un.org/sdg/3 http://metadata.un.org/sdg/4 Ensure healthy lives and promote well-being for all at all ages Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all |
spellingShingle |
Neuropsychological performance Adolescents Arsenic Boston naming test Children Mercury http://metadata.un.org/sdg/3 http://metadata.un.org/sdg/4 Ensure healthy lives and promote well-being for all at all ages Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all Neuropsychological performance Adolescents Arsenic Boston naming test Children Mercury http://metadata.un.org/sdg/3 http://metadata.un.org/sdg/4 Ensure healthy lives and promote well-being for all at all ages Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all De la Ossa, César Argumedos Ramírez-Giraldo, Andrés Fernando Arroyo-Alvis, Katy Marrugo-Negrete, José Díez, Sergi Neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the Mojana region, Colombia |
description |
The present study aims to explore the neuropsychological performance and exposure to mercury (Hg) and arsenic (As) in Colombian children and adolescents considering biomarkers in hair and blood. The total sample consisted of 70 participants from the Mojana region, Colombia. A neuropsychological evaluation protocol was used, consisting of 11 internationally recognized tests, with evidence of national validation and use for measurement in neurotoxicology contexts. A 57.1% of the sample presented levels above the reference value according to the USEPA, the WHO, and the ATSDR for total mercury in hair (HgH), blood mercury (HgB), and/or blood arsenic (AsB). The mean values reported for HgH were 1.76 ± 3.1 μg/g (95% CI 1.02-2.50) with ranges between 0.23 and 17.20; for HgB: 4.11 ± 5.93 μg/l (CI 2.69-5.52), ranging between 0.25 and 25.80, and for AsB: 1.96 ± 2.73 (CI 1.31-2.61) ranging between 0.50 and 15.50. In the comparison of groups in relation to the level of exposure, a significant difference was found (p < 0.05) for the subtest The Boston Naming Test (BNT). Correlation analyses found, on the one hand, significant negative relationships in tests integrated within the verbal (CVB) and executive function (EF) components as well as evidence of positive relationships in the manifestation of errors in their performance with the levels of Hg and/or As transformed by biomarker (Log10). In the linear regression analyses it was found that for each increase in the concentration of HgH, HgB, and AsB it is estimated that, both for the models with and without data adjustment, there is a loss of scores in integrated measures within the CVB and EF for the transformed levels of HgH, HgB, and AsB; and an increase in the reported errors in their processing within these functions. According to these results, exposure to mercury and/or arsenic is related with performance in verbal neuropsychological skills and executive functioning. |
author2 |
0000-0002-8664-2690 |
author_facet |
0000-0002-8664-2690 De la Ossa, César Argumedos Ramírez-Giraldo, Andrés Fernando Arroyo-Alvis, Katy Marrugo-Negrete, José Díez, Sergi |
format |
artículo |
topic_facet |
Neuropsychological performance Adolescents Arsenic Boston naming test Children Mercury http://metadata.un.org/sdg/3 http://metadata.un.org/sdg/4 Ensure healthy lives and promote well-being for all at all ages Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all |
author |
De la Ossa, César Argumedos Ramírez-Giraldo, Andrés Fernando Arroyo-Alvis, Katy Marrugo-Negrete, José Díez, Sergi |
author_sort |
De la Ossa, César Argumedos |
title |
Neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the Mojana region, Colombia |
title_short |
Neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the Mojana region, Colombia |
title_full |
Neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the Mojana region, Colombia |
title_fullStr |
Neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the Mojana region, Colombia |
title_full_unstemmed |
Neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the Mojana region, Colombia |
title_sort |
neuropsychological effects and cognitive deficits associated with exposure to mercury and arsenic in children and adolescents of the mojana region, colombia |
publishDate |
2022-10-18 |
url |
http://hdl.handle.net/10261/283799 https://api.elsevier.com/content/abstract/scopus_id/85141307363 |
work_keys_str_mv |
AT delaossacesarargumedos neuropsychologicaleffectsandcognitivedeficitsassociatedwithexposuretomercuryandarsenicinchildrenandadolescentsofthemojanaregioncolombia AT ramirezgiraldoandresfernando neuropsychologicaleffectsandcognitivedeficitsassociatedwithexposuretomercuryandarsenicinchildrenandadolescentsofthemojanaregioncolombia AT arroyoalviskaty neuropsychologicaleffectsandcognitivedeficitsassociatedwithexposuretomercuryandarsenicinchildrenandadolescentsofthemojanaregioncolombia AT marrugonegretejose neuropsychologicaleffectsandcognitivedeficitsassociatedwithexposuretomercuryandarsenicinchildrenandadolescentsofthemojanaregioncolombia AT diezsergi neuropsychologicaleffectsandcognitivedeficitsassociatedwithexposuretomercuryandarsenicinchildrenandadolescentsofthemojanaregioncolombia |
_version_ |
1802820360799780864 |