Metabolic fate and cardiometabolic effects of phenolic compounds from red-fleshed apple in hypercholesterolemic rats: A comparative study with common white-fleshed apple. The AppleCOR Study

The present study aims to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds provided by a red-fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats are fed with high-fat diet (HFD) to induce hypercholesterolemia and supplemented with red-fleshed apple (HFD+R), white-fleshed apple (HFD+W), or an ACN-rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis, and phenol biological metabolites are determined. Plasma, urine, and feces show a significant increase of ACN metabolites after HFD+R andHFD+A, while flavan-3-ols are significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect sobserved after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function is improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R andHFD+W) is also observed. The findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan-3-ols, together with dihydrochalcones, compose a phenolic phytocomplex in red- and white-fleshed apples, respectively, which can act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats.

Bibliographic Details

Main Authors:	Yuste, Silvia, Ludwig, Iziar A., Romero, María Paz, Piñol-Felis, Carme, Catalán, Úrsula, Pedret, Anna, Valls, Rosa-Maria, Fernández-Castillejo, Sara, Motilva, María-José, Macià, Alba, Rubió, Laura
Other Authors:	Ministerio de Economía y Competitividad (España)
Format:	artículo biblioteca
Published:	John Wiley & Sons 2021-05
Subjects:	Anthocyanins, Aortic thickness, Bowman’s space, Phenolic compounds, Red-fleshed apple, Rustained intake, UPLC-MS/MS,
Online Access:	http://hdl.handle.net/10261/262037 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100009410 http://dx.doi.org/10.13039/501100007512 http://dx.doi.org/10.13039/501100000780
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