Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study.
10 páginas.
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Springer
2013-03
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| Subjects: | Lymphocyte subsets, Celiac disease, Infants, HLA genotype, |
| Online Access: | http://hdl.handle.net/10261/75575 |
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dig-ictan-es-10261-755752022-12-22T08:28:03Z Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study. Pozo Rubio, Tamara Capilla, Amalia Mujico, Jorge R. Palma, Giada de Marcos, Ascensión Sanz Herranz, Yolanda Nova, Esther Lymphocyte subsets Celiac disease Infants HLA genotype 10 páginas. Purpose: In addition to genetic risk, environmental factors might influence celiac disease (CD) development. We sought to assess the effect of the interaction between milk-feeding practices and the HLA-DQ genotype, on peripheral lymphocyte subsets and their activation markers in infants at familial risk for CD. Methods: 170 newborns were classified in 3 different genetic risk groups (high risk, HR; intermediate risk, IR; and low risk, LR) after DQB1 and DQA1 typing. Lymphocyte subsets were studied at the age of 4 months by flow cytometry analysis. Results: 79 infants were receiving exclusive breast-feeding (BF), and 91 partial breast-feeding or formula-feeding (FF). Regarding genetic risk, 40 infants were classified in HR group, 75 in IR group and 55 in LR group. Two-way ANOVA did not show significant interactions between the type of milkfeeding and genetic risk group on the lymphocyte subsets analysed. One-way ANOVA for milk-feeding practice alone showed that the percentage of CD4+CD25+ cells was significantly higher in BF group than in FF group (BF, 10.92±2.71; FF, 9.94±2.96; p=0.026), and absolute counts of CD4+CD38+ cells were significantly higher in FF group than in BF group (FF, 2881.23±973.48; BF, 2557.95±977.06; p=0.038). One-way ANOVA for genetic risk alone showed that absolute counts of NK cells were significantly higher in IR group than HR and LR groups (IR, 539.24±340.63; HR, 405.01±239.53; LR, 419.86±262.85; p=0.028). Conclusion: Lymphocyte subset profiles in the early stages of life could be modulated by milk-feeding practices and genetic risk separately. Breast-feeding might have a positive immunomodulatory effect on lymphocyte subsets in infants at risk for CD. supported by grants AGL2007-66126-C03-01/ALI, AGL2007-66126-C03-02/ALI and AGL2007-66126-C03-03/ALI, from the Spanish Ministry of Science and Innovation and grants 200570F0091 and 200570F0093 from CSIC. Peer reviewed 2013-05-07T10:07:04Z 2013-05-07T10:07:04Z 2013-03 artículo http://purl.org/coar/resource_type/c_6501 European Journal of Nutrition 52 (2) :637-46 (2013) 1436-6207 http://hdl.handle.net/10261/75575 10.1007/s00394-012-0367-8 open Springer |
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España |
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ES |
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dig-ictan-es |
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biblioteca |
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Europa del Sur |
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Biblioteca del ICTAN España |
| topic |
Lymphocyte subsets Celiac disease Infants HLA genotype Lymphocyte subsets Celiac disease Infants HLA genotype |
| spellingShingle |
Lymphocyte subsets Celiac disease Infants HLA genotype Lymphocyte subsets Celiac disease Infants HLA genotype Pozo Rubio, Tamara Capilla, Amalia Mujico, Jorge R. Palma, Giada de Marcos, Ascensión Sanz Herranz, Yolanda Nova, Esther Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study. |
| description |
10 páginas. |
| format |
artículo |
| topic_facet |
Lymphocyte subsets Celiac disease Infants HLA genotype |
| author |
Pozo Rubio, Tamara Capilla, Amalia Mujico, Jorge R. Palma, Giada de Marcos, Ascensión Sanz Herranz, Yolanda Nova, Esther |
| author_facet |
Pozo Rubio, Tamara Capilla, Amalia Mujico, Jorge R. Palma, Giada de Marcos, Ascensión Sanz Herranz, Yolanda Nova, Esther |
| author_sort |
Pozo Rubio, Tamara |
| title |
Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study. |
| title_short |
Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study. |
| title_full |
Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study. |
| title_fullStr |
Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study. |
| title_full_unstemmed |
Influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the PROFICEL study. |
| title_sort |
influence of breastfeeding versus formula feeding on lymphocyte subsets in infants at risk of coeliac disease: the proficel study. |
| publisher |
Springer |
| publishDate |
2013-03 |
| url |
http://hdl.handle.net/10261/75575 |
| work_keys_str_mv |
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| _version_ |
1777670418083086336 |