Breast-feeding modulates the influence of the peroxisome proliferator-activated receptor-γ (PPARG2) Pro12Ala polymorphism on adiposity in adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study

OBJECTIVE - The peroxisome proliferator-activated receptor-γ2 (PPARG2) Pro12Ala polymorphism has been associated with a higher BMI and a lower risk of type 2 diabetes in adulthood. The association between adiposity and PPARG variants can be influenced by environmental factors such as early growth, dietary fat, and (as recently shown) breast-feeding. The objectives of this study were to assess 1) the influence of the PPARG2 Pro12Ala polymorphism on adiposity markers in adolescents and 2) a possible modulating effect of breast-feeding on these associations. RESEARCH DESIGN AND METHODS - Data on breast-feeding duration, BMI, and genotypes for the Pro12Ala polymorphism were available for 945 adolescents (mean age 14.7 years). The breast-feeding duration was obtained from parental records. We measured weight, height, waist circumference, and six skinfold thicknesses. RESULTS - No significant associations between the Pro12Ala polymorphism and any of the above-mentioned anthropometric parameters were found. There were significant interactions between the PPARG2 Pro12Ala polymorphism and breast-feeding with regard to adiposity measurements (all adjusted P<0.05). Indeed, in children who had not been breast-fed, Ala12 allele carriers had higher adiposity parameters (e.g., Δ BMI +1.88 kg/m2, adjusted for age, sex, and center, P=0.007) than Pro12Pro adolescents. In contrast, in breast-fed subjects, there was no significant difference between Ala12 allele carriers and Pro12Pro children in terms of adiposity measurements, whatever the duration of breast-feeding. CONCLUSIONS - Breast-feeding appears to counter the deleterious effect of the PPARG2 Pro12Ala polymorphism on anthropometric parameters in adolescents. © 2010 by the American Diabetes Association.

Bibliographic Details

Main Authors:	Vérier, C., Meirhaeghe, A., Bokor, S., Breidenassel, C., Manios, Yannis, Molnár, Dénes, Artero, Enrique G., Nova, Esther, De Henauw, Stefaan, Moreno, Luis A., Amouyel, Philippe, Labayen, Idoia, Bevilacqua, N., Turck, D., Béghin, Laurent, Dallongeville, J., Gottrand, Frederic
Format:	artículo biblioteca
Language:	English
Published:	American Diabetes Association 2010
Online Access:	http://hdl.handle.net/10261/64152
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