Effects of acute intake of grape/pomegranate pomace dietary supplement on glucose metabolism and oxidative stress in adults with abdominal obesity
A controlled acute, cross-over clinical study (NCT02710461) was performed in order to evaluate the effects on glucose metabolism of a grape/pomegranate pomace dietary supplement in subjects with abdominal obesity (aged 40-60, n = 20). A standard 75 g oral glucose tolerance test (OGTT) was administered alone, together with or 10 h after the consumption of 10 g of the dietary supplement, rich in both extractable (0.4 g) and non-extractable (1.4 g) polyphenols. The dietary supplement did not ameliorate glucose or insulin at any sampling time. No improvement in antioxidant capacity was observed in plasma or urine, concordant with no increased urine polyphenol excretion. A tendency towards improved insulin sensitivity was observed when the product was consumed 10 h before glucose solution. These results suggest that a single realistic dose of grape/pomegranate pomace is not able to clearly improve glucose metabolism; chronic intake remains to be evaluated.
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Format: | artículo biblioteca |
Language: | English |
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Taylor & Francis
2019
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Subjects: | Grape, Abdominal obesity, Metabolic syndrome, Pomace, |
Online Access: | http://hdl.handle.net/10261/203596 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003141 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 |
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dig-ictan-es-10261-2035962020-05-07T04:30:38Z Effects of acute intake of grape/pomegranate pomace dietary supplement on glucose metabolism and oxidative stress in adults with abdominal obesity Pérez-Ramírez, Iza F. Hernández de Diego, Elena Riomoros-Arranz, Marta Reynoso-Camacho, Rosalía Saura Calixto, Fulgencio D. Pérez-Jiménez, Jara Ministerio de Ciencia e Innovación (España) Ministerio de Economía y Competitividad (España) European Commission Consejo Nacional de Ciencia y Tecnología (México) Grape Abdominal obesity Metabolic syndrome Pomace A controlled acute, cross-over clinical study (NCT02710461) was performed in order to evaluate the effects on glucose metabolism of a grape/pomegranate pomace dietary supplement in subjects with abdominal obesity (aged 40-60, n = 20). A standard 75 g oral glucose tolerance test (OGTT) was administered alone, together with or 10 h after the consumption of 10 g of the dietary supplement, rich in both extractable (0.4 g) and non-extractable (1.4 g) polyphenols. The dietary supplement did not ameliorate glucose or insulin at any sampling time. No improvement in antioxidant capacity was observed in plasma or urine, concordant with no increased urine polyphenol excretion. A tendency towards improved insulin sensitivity was observed when the product was consumed 10 h before glucose solution. These results suggest that a single realistic dose of grape/pomegranate pomace is not able to clearly improve glucose metabolism; chronic intake remains to be evaluated. This work was supported by the Spanish Ministry of Science and Innovation (MINECO-FEDER) under grant AGL2014-55102-JIN and by Consejo Nacional de Ciencia y Tecnologia (CONACyT) (international scholarship, I.F.P.-R.) Peer reviewed 2020-03-11T12:41:37Z 2020-03-11T12:41:37Z 2019 artículo http://purl.org/coar/resource_type/c_6501 International Journal of Food Sciences and Nutrition 71(1): 94-105 (2019) 0963-7486 http://hdl.handle.net/10261/203596 10.1080/09637486.2019.1607831 1465-3478 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003141 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 31062633 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2014-55102-JIN https://doi.org/10.1080/09637486.2019.1607831 Sí open Taylor & Francis |
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Grape Abdominal obesity Metabolic syndrome Pomace Grape Abdominal obesity Metabolic syndrome Pomace |
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Grape Abdominal obesity Metabolic syndrome Pomace Grape Abdominal obesity Metabolic syndrome Pomace Pérez-Ramírez, Iza F. Hernández de Diego, Elena Riomoros-Arranz, Marta Reynoso-Camacho, Rosalía Saura Calixto, Fulgencio D. Pérez-Jiménez, Jara Effects of acute intake of grape/pomegranate pomace dietary supplement on glucose metabolism and oxidative stress in adults with abdominal obesity |
description |
A controlled acute, cross-over clinical study (NCT02710461) was performed in order to evaluate the effects on glucose metabolism of a grape/pomegranate pomace dietary supplement in subjects with abdominal obesity (aged 40-60, n = 20). A standard 75 g oral glucose tolerance test (OGTT) was administered alone, together with or 10 h after the consumption of 10 g of the dietary supplement, rich in both extractable (0.4 g) and non-extractable (1.4 g) polyphenols. The dietary supplement did not ameliorate glucose or insulin at any sampling time. No improvement in antioxidant capacity was observed in plasma or urine, concordant with no increased urine polyphenol excretion. A tendency towards improved insulin sensitivity was observed when the product was consumed 10 h before glucose solution. These results suggest that a single realistic dose of grape/pomegranate pomace is not able to clearly improve glucose metabolism; chronic intake remains to be evaluated. |
author2 |
Ministerio de Ciencia e Innovación (España) |
author_facet |
Ministerio de Ciencia e Innovación (España) Pérez-Ramírez, Iza F. Hernández de Diego, Elena Riomoros-Arranz, Marta Reynoso-Camacho, Rosalía Saura Calixto, Fulgencio D. Pérez-Jiménez, Jara |
format |
artículo |
topic_facet |
Grape Abdominal obesity Metabolic syndrome Pomace |
author |
Pérez-Ramírez, Iza F. Hernández de Diego, Elena Riomoros-Arranz, Marta Reynoso-Camacho, Rosalía Saura Calixto, Fulgencio D. Pérez-Jiménez, Jara |
author_sort |
Pérez-Ramírez, Iza F. |
title |
Effects of acute intake of grape/pomegranate pomace dietary supplement on glucose metabolism and oxidative stress in adults with abdominal obesity |
title_short |
Effects of acute intake of grape/pomegranate pomace dietary supplement on glucose metabolism and oxidative stress in adults with abdominal obesity |
title_full |
Effects of acute intake of grape/pomegranate pomace dietary supplement on glucose metabolism and oxidative stress in adults with abdominal obesity |
title_fullStr |
Effects of acute intake of grape/pomegranate pomace dietary supplement on glucose metabolism and oxidative stress in adults with abdominal obesity |
title_full_unstemmed |
Effects of acute intake of grape/pomegranate pomace dietary supplement on glucose metabolism and oxidative stress in adults with abdominal obesity |
title_sort |
effects of acute intake of grape/pomegranate pomace dietary supplement on glucose metabolism and oxidative stress in adults with abdominal obesity |
publisher |
Taylor & Francis |
publishDate |
2019 |
url |
http://hdl.handle.net/10261/203596 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003141 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 |
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