Sesquiterpene Lactones from Artemisia absinthium. Biotransformation and Rearrangement of the Insect Antifeedant 3α-hydroxypelenolide

Three new compounds, the sesquiterpenes absilactone and hansonlactone and the acetophenone derivative ajenjol, have been isolated from a cultivated variety of Artemisia absinthium. In addition, the major lactone isolated, 3α-hydroxypelenolide, was biotransformed by the fungus Mucor plumbeus affording the corresponding 1β, 10α-epoxide. A cadinane derivative was formed by an acid rearrangement produced in the culture medium, but not by the enzymatic system of the fungus. Furthermore, 3α-hydroxypelenolide showed strong antifeedant effects against Leptinotarsa decemlineata and cytotoxic activity to Sf9 insect cells, while the biotransformed compounds showed antifeedant postingestive effects against Spodoptera littoralis

Bibliographic Details

Main Authors:	Fraga, Braulio M., Díaz, Carmen E., Bailén, María, González-Coloma, Azucena
Other Authors:	European Commission
Format:	artículo biblioteca
Language:	English
Published:	Multidisciplinary Digital Publishing Institute 2021-04-28
Subjects:	Artemisia absinthium, Asteraceae, Absilactone, Hansonlactone, Ajenjol, Mucor plumbeus, Biotransformations, 3α-hydroxypelenolide, Biological activities,
Online Access:	http://hdl.handle.net/10261/240067 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837
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