Image2_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG
Humans have a great diversity in phenotypes, influenced by genetic, environmental, nutritional, cultural, and social factors. Understanding the historical trends of physiological traits can shed light on human physiology, as well as elucidate the factors that influence human diseases. Here we built genome-wide polygenic scores for heritable traits, including height, body mass index, lipoprotein concentrations, cardiovascular disease, and intelligence, using summary statistics of genome-wide association studies in Europeans. Subsequently, we applied these scores to the genomes of ancient European populations. Our results revealed that after the Neolithic, European populations experienced an increase in height and intelligence scores, decreased their skin pigmentation, while the risk for coronary artery disease increased through a genetic trajectory favoring low HDL concentrations. These results are a reflection of the continuous evolutionary processes in humans and highlight the impact that the Neolithic revolution had on our lifestyle and health.
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2022-03-28
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Subjects: | Evolution, Complex traits, Neolithic revolution, Human genetics, Polygenic risk scores (PRS), |
Online Access: | http://hdl.handle.net/10261/311257 |
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dig-ibe-es-10261-3112572023-06-12T11:55:38Z Image2_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG Kuijpers, Yunus Domínguez-Andrés, Jorge Bakker, Olivier B. Gupta, Manoj Kumar Grasshoff, Martin Xu, Cheng-Jian Joosten, Leo A. B. Bertranpetit, Jaume Netea, Mihai G. Li, Yang Evolution Complex traits Neolithic revolution Human genetics Polygenic risk scores (PRS) Humans have a great diversity in phenotypes, influenced by genetic, environmental, nutritional, cultural, and social factors. Understanding the historical trends of physiological traits can shed light on human physiology, as well as elucidate the factors that influence human diseases. Here we built genome-wide polygenic scores for heritable traits, including height, body mass index, lipoprotein concentrations, cardiovascular disease, and intelligence, using summary statistics of genome-wide association studies in Europeans. Subsequently, we applied these scores to the genomes of ancient European populations. Our results revealed that after the Neolithic, European populations experienced an increase in height and intelligence scores, decreased their skin pigmentation, while the risk for coronary artery disease increased through a genetic trajectory favoring low HDL concentrations. These results are a reflection of the continuous evolutionary processes in humans and highlight the impact that the Neolithic revolution had on our lifestyle and health. Peer reviewed 2023-06-12T11:55:38Z 2023-06-12T11:55:38Z 2022-03-28 dataset Kuijpers, Yunus; Domínguez-Andrés, Jorge; Bakker, Olivier B; Gupta, Manoj Kumar; Grasshoff, Martin; Xu, Cheng-Jian; Joosten, Leo A. B.; Bertranpetit, Jaume; Netea, Mihai G.; Li, Yang; 2022; Image2_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG [Dataset]; Figshare; https://doi.org/10.3389/fgene.2022.833190.s002 http://hdl.handle.net/10261/311257 10.3389/fgene.2022.833190.s002 en Kuijpers, Yunus; Domínguez-Andrés, Jorge; Bakker, Olivier B; Gupta, Manoj Kumar; Grasshoff, Martin; Xu, Cheng-Jian; Joosten, Leo A. B.; Bertranpetit, Jaume; Netea, Mihai G.; Li, Yang. Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans. https://doi.org/10.3389/fgene.2022.833190 . http://hdl.handle.net/10261/272056 https://doi.org/10.3389/fgene.2022.833190.s002 Sí open image/jpeg Figshare |
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Evolution Complex traits Neolithic revolution Human genetics Polygenic risk scores (PRS) Evolution Complex traits Neolithic revolution Human genetics Polygenic risk scores (PRS) |
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Evolution Complex traits Neolithic revolution Human genetics Polygenic risk scores (PRS) Evolution Complex traits Neolithic revolution Human genetics Polygenic risk scores (PRS) Kuijpers, Yunus Domínguez-Andrés, Jorge Bakker, Olivier B. Gupta, Manoj Kumar Grasshoff, Martin Xu, Cheng-Jian Joosten, Leo A. B. Bertranpetit, Jaume Netea, Mihai G. Li, Yang Image2_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG |
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Humans have a great diversity in phenotypes, influenced by genetic, environmental, nutritional, cultural, and social factors. Understanding the historical trends of physiological traits can shed light on human physiology, as well as elucidate the factors that influence human diseases. Here we built genome-wide polygenic scores for heritable traits, including height, body mass index, lipoprotein concentrations, cardiovascular disease, and intelligence, using summary statistics of genome-wide association studies in Europeans. Subsequently, we applied these scores to the genomes of ancient European populations. Our results revealed that after the Neolithic, European populations experienced an increase in height and intelligence scores, decreased their skin pigmentation, while the risk for coronary artery disease increased through a genetic trajectory favoring low HDL concentrations. These results are a reflection of the continuous evolutionary processes in humans and highlight the impact that the Neolithic revolution had on our lifestyle and health. |
format |
dataset |
topic_facet |
Evolution Complex traits Neolithic revolution Human genetics Polygenic risk scores (PRS) |
author |
Kuijpers, Yunus Domínguez-Andrés, Jorge Bakker, Olivier B. Gupta, Manoj Kumar Grasshoff, Martin Xu, Cheng-Jian Joosten, Leo A. B. Bertranpetit, Jaume Netea, Mihai G. Li, Yang |
author_facet |
Kuijpers, Yunus Domínguez-Andrés, Jorge Bakker, Olivier B. Gupta, Manoj Kumar Grasshoff, Martin Xu, Cheng-Jian Joosten, Leo A. B. Bertranpetit, Jaume Netea, Mihai G. Li, Yang |
author_sort |
Kuijpers, Yunus |
title |
Image2_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG |
title_short |
Image2_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG |
title_full |
Image2_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG |
title_fullStr |
Image2_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG |
title_full_unstemmed |
Image2_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG |
title_sort |
image2_evolutionary trajectories of complex traits in european populations of modern humans.jpeg |
publisher |
Figshare |
publishDate |
2022-03-28 |
url |
http://hdl.handle.net/10261/311257 |
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