Image4_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG
Humans have a great diversity in phenotypes, influenced by genetic, environmental, nutritional, cultural, and social factors. Understanding the historical trends of physiological traits can shed light on human physiology, as well as elucidate the factors that influence human diseases. Here we built genome-wide polygenic scores for heritable traits, including height, body mass index, lipoprotein concentrations, cardiovascular disease, and intelligence, using summary statistics of genome-wide association studies in Europeans. Subsequently, we applied these scores to the genomes of ancient European populations. Our results revealed that after the Neolithic, European populations experienced an increase in height and intelligence scores, decreased their skin pigmentation, while the risk for coronary artery disease increased through a genetic trajectory favoring low HDL concentrations. These results are a reflection of the continuous evolutionary processes in humans and highlight the impact that the Neolithic revolution had on our lifestyle and health.
Main Authors: | , , , , , , , , , |
---|---|
Format: | dataset biblioteca |
Language: | English |
Published: |
Figshare
2022-03-28
|
Subjects: | Evolution, Complex traits, Neolithic revolution, Human genetics, Polygenic risk scores (PRS), |
Online Access: | http://hdl.handle.net/10261/311249 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-ibe-es-10261-311249 |
---|---|
record_format |
koha |
spelling |
dig-ibe-es-10261-3112492023-06-12T11:39:55Z Image4_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG Kuijpers, Yunus Domínguez-Andrés, Jorge Bakker, Olivier B. Gupta, Manoj Kumar Grasshoff, Martin Xu, Cheng-Jian Joosten, Leo A. B. Bertranpetit, Jaume Netea, Mihai G. Li, Yang Evolution Complex traits Neolithic revolution Human genetics Polygenic risk scores (PRS) Humans have a great diversity in phenotypes, influenced by genetic, environmental, nutritional, cultural, and social factors. Understanding the historical trends of physiological traits can shed light on human physiology, as well as elucidate the factors that influence human diseases. Here we built genome-wide polygenic scores for heritable traits, including height, body mass index, lipoprotein concentrations, cardiovascular disease, and intelligence, using summary statistics of genome-wide association studies in Europeans. Subsequently, we applied these scores to the genomes of ancient European populations. Our results revealed that after the Neolithic, European populations experienced an increase in height and intelligence scores, decreased their skin pigmentation, while the risk for coronary artery disease increased through a genetic trajectory favoring low HDL concentrations. These results are a reflection of the continuous evolutionary processes in humans and highlight the impact that the Neolithic revolution had on our lifestyle and health. Peer reviewed 2023-06-12T11:35:35Z 2023-06-12T11:35:35Z 2022-03-28 dataset Kuijpers, Yunus; Domínguez-Andrés, Jorge; Bakker, Olivier B; Gupta, Manoj Kumar; Grasshoff, Martin; Xu, Cheng-Jian; Joosten, Leo A. B.; Bertranpetit, Jaume; Netea, Mihai G.; Li, Yang; 2022; Image4_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG [Dataset]; Figshare; https://doi.org/10.3389/fgene.2022.833190.s004 http://hdl.handle.net/10261/311249 10.3389/fgene.2022.833190.s004 en Kuijpers, Yunus; Domínguez-Andrés, Jorge; Bakker, Olivier B; Gupta, Manoj Kumar; Grasshoff, Martin; Xu, Cheng-Jian; Joosten, Leo A. B.; Bertranpetit, Jaume; Netea, Mihai G.; Li, Yang. Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans. https://doi.org/10.3389/fgene.2022.833190 . http://hdl.handle.net/10261/272056 https://doi.org/10.3389/fgene.2022.833190.s004 Sí open image/jpeg Figshare |
institution |
IBE ES |
collection |
DSpace |
country |
España |
countrycode |
ES |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-ibe-es |
tag |
biblioteca |
region |
Europa del Sur |
libraryname |
Biblioteca del IBE España |
language |
English |
topic |
Evolution Complex traits Neolithic revolution Human genetics Polygenic risk scores (PRS) Evolution Complex traits Neolithic revolution Human genetics Polygenic risk scores (PRS) |
spellingShingle |
Evolution Complex traits Neolithic revolution Human genetics Polygenic risk scores (PRS) Evolution Complex traits Neolithic revolution Human genetics Polygenic risk scores (PRS) Kuijpers, Yunus Domínguez-Andrés, Jorge Bakker, Olivier B. Gupta, Manoj Kumar Grasshoff, Martin Xu, Cheng-Jian Joosten, Leo A. B. Bertranpetit, Jaume Netea, Mihai G. Li, Yang Image4_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG |
description |
Humans have a great diversity in phenotypes, influenced by genetic, environmental, nutritional, cultural, and social factors. Understanding the historical trends of physiological traits can shed light on human physiology, as well as elucidate the factors that influence human diseases. Here we built genome-wide polygenic scores for heritable traits, including height, body mass index, lipoprotein concentrations, cardiovascular disease, and intelligence, using summary statistics of genome-wide association studies in Europeans. Subsequently, we applied these scores to the genomes of ancient European populations. Our results revealed that after the Neolithic, European populations experienced an increase in height and intelligence scores, decreased their skin pigmentation, while the risk for coronary artery disease increased through a genetic trajectory favoring low HDL concentrations. These results are a reflection of the continuous evolutionary processes in humans and highlight the impact that the Neolithic revolution had on our lifestyle and health. |
format |
dataset |
topic_facet |
Evolution Complex traits Neolithic revolution Human genetics Polygenic risk scores (PRS) |
author |
Kuijpers, Yunus Domínguez-Andrés, Jorge Bakker, Olivier B. Gupta, Manoj Kumar Grasshoff, Martin Xu, Cheng-Jian Joosten, Leo A. B. Bertranpetit, Jaume Netea, Mihai G. Li, Yang |
author_facet |
Kuijpers, Yunus Domínguez-Andrés, Jorge Bakker, Olivier B. Gupta, Manoj Kumar Grasshoff, Martin Xu, Cheng-Jian Joosten, Leo A. B. Bertranpetit, Jaume Netea, Mihai G. Li, Yang |
author_sort |
Kuijpers, Yunus |
title |
Image4_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG |
title_short |
Image4_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG |
title_full |
Image4_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG |
title_fullStr |
Image4_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG |
title_full_unstemmed |
Image4_Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans.JPEG |
title_sort |
image4_evolutionary trajectories of complex traits in european populations of modern humans.jpeg |
publisher |
Figshare |
publishDate |
2022-03-28 |
url |
http://hdl.handle.net/10261/311249 |
work_keys_str_mv |
AT kuijpersyunus image4evolutionarytrajectoriesofcomplextraitsineuropeanpopulationsofmodernhumansjpeg AT dominguezandresjorge image4evolutionarytrajectoriesofcomplextraitsineuropeanpopulationsofmodernhumansjpeg AT bakkerolivierb image4evolutionarytrajectoriesofcomplextraitsineuropeanpopulationsofmodernhumansjpeg AT guptamanojkumar image4evolutionarytrajectoriesofcomplextraitsineuropeanpopulationsofmodernhumansjpeg AT grasshoffmartin image4evolutionarytrajectoriesofcomplextraitsineuropeanpopulationsofmodernhumansjpeg AT xuchengjian image4evolutionarytrajectoriesofcomplextraitsineuropeanpopulationsofmodernhumansjpeg AT joostenleoab image4evolutionarytrajectoriesofcomplextraitsineuropeanpopulationsofmodernhumansjpeg AT bertranpetitjaume image4evolutionarytrajectoriesofcomplextraitsineuropeanpopulationsofmodernhumansjpeg AT neteamihaig image4evolutionarytrajectoriesofcomplextraitsineuropeanpopulationsofmodernhumansjpeg AT liyang image4evolutionarytrajectoriesofcomplextraitsineuropeanpopulationsofmodernhumansjpeg |
_version_ |
1777668838523928576 |