Human herpesvirus diversity is altered in HLA class I binding peptides
[Significance] Viruses evolve to evade immune recognition that may otherwise limit transmission. Presentation of virus peptides by human leukocyte antigen (HLA) class I is a necessary step in the recognition of infection by immune cells. Virus adaptation to evade this immune recognition has not been formally tested across the diversity of HLA class I allotypes and virus strains. We analyzed genetic diversity of three human herpesviruses across peptides that bind diverse HLA class I allotypes. We find that adaptation to evade HLA class I recognition may be a general phenomenon shaping human herpesvirus genetic diversity, particularly for those proteins expressed during viral latency. This broad scope, across human and virus diversity, provides a unique comparative perspective of human–herpesvirus coevolution.
Main Authors: | Palmer, William H., Telford, Marco, Navarro, Arcadi, Santpere, Gabriel, Norman, Paul J. |
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Other Authors: | National Institutes of Health (US) |
Format: | artículo biblioteca |
Language: | English |
Published: |
National Academy of Sciences (U.S.)
2022-04-29
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Subjects: | HLA, Herpesvirus, Population genetics, EBV, HCMV, |
Online Access: | http://hdl.handle.net/10261/272143 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/100000002 |
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