A catalog of single nucleotide changes distinguishing modern humans from archaic hominins
Throughout the past decade, studying ancient genomes has provided unique insights into human prehistory, and differences between modern humans and other branches like Neanderthals can enrich our understanding of the molecular basis of unique modern human traits. Modern human variation and the interactions between different hominin lineages are now well studied, making it reasonable to go beyond fixed genetic changes and explore changes that are observed at high frequency in present-day humans. Here, we identify 571 genes with non-synonymous changes at high frequency. We suggest that molecular mechanisms in cell division and networks affecting cellular features of neurons were prominently modified by these changes. Complex phenotypes in brain growth trajectory and cognitive traits are likely influenced by these networks and other non-coding changes presented here. We propose that at least some of these changes contributed to uniquely human traits, and should be prioritized for experimental validation.
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Springer Nature
2019-06-11
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Subjects: | Evolutionary biology, Evolutionary genetics, |
Online Access: | http://hdl.handle.net/10261/205915 http://dx.doi.org/10.13039/501100001659 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100002809 |
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dig-ibe-es-10261-2059152021-12-28T16:26:49Z A catalog of single nucleotide changes distinguishing modern humans from archaic hominins Kuhlwilm, Martin Boeckx, Cedric German Research Foundation La Caixa Ministerio de Economía y Competitividad (España) European Commission Ministerio de Ciencia e Innovación (España) Generalitat de Catalunya Evolutionary biology Evolutionary genetics Throughout the past decade, studying ancient genomes has provided unique insights into human prehistory, and differences between modern humans and other branches like Neanderthals can enrich our understanding of the molecular basis of unique modern human traits. Modern human variation and the interactions between different hominin lineages are now well studied, making it reasonable to go beyond fixed genetic changes and explore changes that are observed at high frequency in present-day humans. Here, we identify 571 genes with non-synonymous changes at high frequency. We suggest that molecular mechanisms in cell division and networks affecting cellular features of neurons were prominently modified by these changes. Complex phenotypes in brain growth trajectory and cognitive traits are likely influenced by these networks and other non-coding changes presented here. We propose that at least some of these changes contributed to uniquely human traits, and should be prioritized for experimental validation. M.K. was supported by a Deutsche Forschungsgemeinschaft (DFG) fellowship (KU 3467/1-1) and the Postdoctoral Junior Leader Fellowship Programme from “la Caixa” Banking Foundation (LCF/BQ/PR19/11700002). C.B. acknowledges research funds from the Spanish Ministry of Economy and Competitiveness/FEDER (grant FFI2016-78034-C2-1-P), Marie Curie International Reintegration Grant from the European Union (PIRG-GA-2009-256413), research funds from the Fundació Bosch i Gimpera, MEXT/JSPS Grant-in-Aid for Scientific Research on Innovative Areas 4903 (Evolinguistics: JP17H06379), and Generalitat de Catalunya (Government of Catalonia) – 2017-SGR-341. 2020-03-31T09:02:13Z 2020-03-31T09:02:13Z 2019-06-11 2020-03-31T09:02:14Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1038/s41598-019-44877-x issn: 2045-2322 Scientific Reports 9: 8463 (2019) http://hdl.handle.net/10261/205915 10.1038/s41598-019-44877-x http://dx.doi.org/10.13039/501100001659 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100002809 31186485 #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FFI2016-78034-C2-1-P info:eu-repo/grantAgreement/EC/FP7/256413 Publisher's version http://doi.org/10.1038/s41598-019-44877-x Sí open Springer Nature |
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Evolutionary biology Evolutionary genetics Evolutionary biology Evolutionary genetics Kuhlwilm, Martin Boeckx, Cedric A catalog of single nucleotide changes distinguishing modern humans from archaic hominins |
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Throughout the past decade, studying ancient genomes has provided unique insights into human prehistory, and differences between modern humans and other branches like Neanderthals can enrich our understanding of the molecular basis of unique modern human traits. Modern human variation and the interactions between different hominin lineages are now well studied, making it reasonable to go beyond fixed genetic changes and explore changes that are observed at high frequency in present-day humans. Here, we identify 571 genes with non-synonymous changes at high frequency. We suggest that molecular mechanisms in cell division and networks affecting cellular features of neurons were prominently modified by these changes. Complex phenotypes in brain growth trajectory and cognitive traits are likely influenced by these networks and other non-coding changes presented here. We propose that at least some of these changes contributed to uniquely human traits, and should be prioritized for experimental validation. |
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German Research Foundation |
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German Research Foundation Kuhlwilm, Martin Boeckx, Cedric |
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artículo |
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Evolutionary biology Evolutionary genetics |
author |
Kuhlwilm, Martin Boeckx, Cedric |
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Kuhlwilm, Martin |
title |
A catalog of single nucleotide changes distinguishing modern humans from archaic hominins |
title_short |
A catalog of single nucleotide changes distinguishing modern humans from archaic hominins |
title_full |
A catalog of single nucleotide changes distinguishing modern humans from archaic hominins |
title_fullStr |
A catalog of single nucleotide changes distinguishing modern humans from archaic hominins |
title_full_unstemmed |
A catalog of single nucleotide changes distinguishing modern humans from archaic hominins |
title_sort |
catalog of single nucleotide changes distinguishing modern humans from archaic hominins |
publisher |
Springer Nature |
publishDate |
2019-06-11 |
url |
http://hdl.handle.net/10261/205915 http://dx.doi.org/10.13039/501100001659 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100002809 |
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