Natural Selection in the Great Apes
Natural selection is crucial for the adaptation of populations to their environments. Here, we present the first global study of natural selection in the Hominidae (humans and great apes) based on genome-wide information from population samples representing all extant species (including most subspecies). Combining several neutrality tests we create a multi-species map of signatures of natural selection covering all major types of natural selection. We find that the estimated efficiency of both purifying and positive selection varies between species and is significantly correlated with their long-term effective population size. Thus, even the modest differences in population size among the closely related Hominidae lineages have resulted in differences in their ability to remove deleterious alleles and to adapt to changing environments. Most signatures of balancing and positive selection are species-specific, with signatures of balancing selection more often being shared among species. We also identify loci with evidence of positive selection across several lineages. Notably, we detect signatures of positive selection in several genes related to brain function, anatomy, diet and immune processes. Our results contribute to a better understanding of human evolution by putting the evidence of natural selection in humans within its larger evolutionary context. The global map of natural selection in our closest living relatives is available as an interactive browser at http://tinyurl.com/nf8qmzh.
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Format: | artículo biblioteca |
Language: | English |
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Oxford University Press
2016-12
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Subjects: | Evolution, Adaptation, Comparative genomics, Primates, |
Online Access: | http://hdl.handle.net/10261/151993 http://dx.doi.org/10.13039/501100004189 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100003043 http://dx.doi.org/10.13039/501100004837 |
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dig-ibe-es-10261-1519932021-12-27T16:54:06Z Natural Selection in the Great Apes Cagan, Alexander Theunert, Christoph Laayouni, Hafid Santpere, Gabriel Pybus, Marc Casals, Ferran Prüfer, Kay Navarro, Arcadi Marqués-Bonet, Tomàs Bertranpetit, Jaume Andrés, Aida M. Max Planck Society Ministerio de Economía y Competitividad (España) Generalitat de Catalunya European Research Council EMBO Ministerio de Ciencia e Innovación (España) Evolution Adaptation Comparative genomics Primates Natural selection is crucial for the adaptation of populations to their environments. Here, we present the first global study of natural selection in the Hominidae (humans and great apes) based on genome-wide information from population samples representing all extant species (including most subspecies). Combining several neutrality tests we create a multi-species map of signatures of natural selection covering all major types of natural selection. We find that the estimated efficiency of both purifying and positive selection varies between species and is significantly correlated with their long-term effective population size. Thus, even the modest differences in population size among the closely related Hominidae lineages have resulted in differences in their ability to remove deleterious alleles and to adapt to changing environments. Most signatures of balancing and positive selection are species-specific, with signatures of balancing selection more often being shared among species. We also identify loci with evidence of positive selection across several lineages. Notably, we detect signatures of positive selection in several genes related to brain function, anatomy, diet and immune processes. Our results contribute to a better understanding of human evolution by putting the evidence of natural selection in humans within its larger evolutionary context. The global map of natural selection in our closest living relatives is available as an interactive browser at http://tinyurl.com/nf8qmzh. This work was supported by funding from the Max Planck Society to K.P. and A.M.A.; by grants from the Ministerio de Economía y Competitividad in Spain (grant BFU2013-43726-P) and the Secretaria d’Universitats i Recerca de la Generalitat de Catalunya (grant GRC 2014 SGR 866) to J.B.; by an European Research Council Advanced Grant (233297) to S.Pääbo and European Research Council Starting Grant (260372) to T.M.B.; and by European Molecular Biology Organization Young Investigator Award and Ministerio de Ciencia e Innovación in Spain (BFU2014-55090-P) to T.M.B. Peer reviewed 2017-06-26T07:03:41Z 2017-06-26T07:03:41Z 2016-12 artículo http://purl.org/coar/resource_type/c_6501 Molecular Biology and Evolution 33(12): 3268-3283 (2016) 0737-4038 http://hdl.handle.net/10261/151993 10.1093/molbev/msw215 1537-1719 http://dx.doi.org/10.13039/501100004189 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100003043 http://dx.doi.org/10.13039/501100004837 27795229 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-43726-P info:eu-repo/grantAgreement/EC/FP7/233297 info:eu-repo/grantAgreement/EC/FP7/260372 Publisher's version https://doi.org/10.1093/molbev/msw215 Sí open Oxford University Press |
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Evolution Adaptation Comparative genomics Primates Evolution Adaptation Comparative genomics Primates Cagan, Alexander Theunert, Christoph Laayouni, Hafid Santpere, Gabriel Pybus, Marc Casals, Ferran Prüfer, Kay Navarro, Arcadi Marqués-Bonet, Tomàs Bertranpetit, Jaume Andrés, Aida M. Natural Selection in the Great Apes |
description |
Natural selection is crucial for the adaptation of populations to their environments. Here, we present the first global study of natural selection in the Hominidae (humans and great apes) based on genome-wide information from population samples representing all extant species (including most subspecies). Combining several neutrality tests we create a multi-species map of signatures of natural selection covering all major types of natural selection. We find that the estimated efficiency of both purifying and positive selection varies between species and is significantly correlated with their long-term effective population size. Thus, even the modest differences in population size among the closely related Hominidae lineages have resulted in differences in their ability to remove deleterious alleles and to adapt to changing environments. Most signatures of balancing and positive selection are species-specific, with signatures of balancing selection more often being shared among species. We also identify loci with evidence of positive selection across several lineages. Notably, we detect signatures of positive selection in several genes related to brain function, anatomy, diet and immune processes. Our results contribute to a better understanding of human evolution by putting the evidence of natural selection in humans within its larger evolutionary context. The global map of natural selection in our closest living relatives is available as an interactive browser at http://tinyurl.com/nf8qmzh. |
author2 |
Max Planck Society |
author_facet |
Max Planck Society Cagan, Alexander Theunert, Christoph Laayouni, Hafid Santpere, Gabriel Pybus, Marc Casals, Ferran Prüfer, Kay Navarro, Arcadi Marqués-Bonet, Tomàs Bertranpetit, Jaume Andrés, Aida M. |
format |
artículo |
topic_facet |
Evolution Adaptation Comparative genomics Primates |
author |
Cagan, Alexander Theunert, Christoph Laayouni, Hafid Santpere, Gabriel Pybus, Marc Casals, Ferran Prüfer, Kay Navarro, Arcadi Marqués-Bonet, Tomàs Bertranpetit, Jaume Andrés, Aida M. |
author_sort |
Cagan, Alexander |
title |
Natural Selection in the Great Apes |
title_short |
Natural Selection in the Great Apes |
title_full |
Natural Selection in the Great Apes |
title_fullStr |
Natural Selection in the Great Apes |
title_full_unstemmed |
Natural Selection in the Great Apes |
title_sort |
natural selection in the great apes |
publisher |
Oxford University Press |
publishDate |
2016-12 |
url |
http://hdl.handle.net/10261/151993 http://dx.doi.org/10.13039/501100004189 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100000781 http://dx.doi.org/10.13039/501100003043 http://dx.doi.org/10.13039/501100004837 |
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