Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study

Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study

[Background] Chronic postsurgical pain (CPSP) has been linked to many surgical settings. The authors aimed to analyze functional genetic polymorphisms and clinical factors that might identify CPSP risk after inguinal hernia repair, hysterectomy, and thoracotomy.

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Main Authors: Montes, Antonio, Roca, Gisela, Sabate, Sergi, Lao, José Ignacio, Navarro, Arcadi, Cantillo, Jordi, Canet, Jaume, GENDOLCAT Study Group
Other Authors: Fundació La Marató de TV3
Format: artículo biblioteca
Language:English
Published: Lippincott Williams & Wilkins 2015-05
Online Access:http://hdl.handle.net/10261/151595
http://dx.doi.org/10.13039/100008666
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spelling dig-ibe-es-10261-1515952019-03-05T12:32:37Z Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study Montes, Antonio Roca, Gisela Sabate, Sergi Lao, José Ignacio Navarro, Arcadi Cantillo, Jordi Canet, Jaume GENDOLCAT Study Group Fundació La Marató de TV3 [Background] Chronic postsurgical pain (CPSP) has been linked to many surgical settings. The authors aimed to analyze functional genetic polymorphisms and clinical factors that might identify CPSP risk after inguinal hernia repair, hysterectomy, and thoracotomy. [Methods] This prospective multicenter cohort study enrolled 2,929 patients scheduled for inguinal hernia repair, hysterectomy (vaginal or abdominal), or thoracotomy. The main outcome was the incidence of CPSP confirmed by physical examination 4 months after surgery. The secondary outcome was CPSP incidences at 12 and 24 months. The authors also tested the associations between CPSP and 90 genetic markers plus a series of clinical factors and built a CPSP risk model. [Results] Within a median of 4.4 months, CPSP had developed in 527 patients (18.0%), in 13.6% after hernia repair, 11.8% after vaginal hysterectomy, 25.1% after abdominal hysterectomy, and 37.6% after thoracotomy. CPSP persisted after a median of 14.6 months and 26.3 months in 6.2% and 4.1%, respectively, after hernia repair, 4.1% and 2.2% after vaginal hysterectomy, 9.9% and 6.7% after abdominal hysterectomy, and 19.1% and 13.2% after thoracotomy. No significant genetic differences between cases and controls were identified. The risk model included six clinical predictors: (1) surgical procedure, (2) age, (3) physical health (Short Form Health Survey-12), (4) mental health (Short Form Health Survey-12), (5) preoperative pain in the surgical field, and (6) preoperative pain in another area. Discrimination was moderate (c-statistic, 0.731; 95% CI, 0.705 to 0.755). [Conclusions] Until unequivocal genetic predictors of CPSP are understood, the authors encourage systematic use of clinical factors for predicting and managing CPSP risk. This study was supported by grant 071210-2007 from Fundació La Marató de TV3 (Catalan public television network marathon foundation, Barcelona, Spain). Peer reviewed 2017-06-19T06:57:04Z 2017-06-19T06:57:04Z 2015-05 artículo http://purl.org/coar/resource_type/c_6501 Anesthesiology 122(5): 1123-1141 (2015) 0003-3022 http://hdl.handle.net/10261/151595 10.1097/ALN.0000000000000611 1528-1175 http://dx.doi.org/10.13039/100008666 en http://doi.org/10.1097/ALN.0000000000000611 Sí none Lippincott Williams & Wilkins
institution IBE ES
collection DSpace
country España
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component Bibliográfico
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databasecode dig-ibe-es
tag biblioteca
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libraryname Biblioteca del IBE España
language English
description [Background] Chronic postsurgical pain (CPSP) has been linked to many surgical settings. The authors aimed to analyze functional genetic polymorphisms and clinical factors that might identify CPSP risk after inguinal hernia repair, hysterectomy, and thoracotomy.
author2 Fundació La Marató de TV3
author_facet Fundació La Marató de TV3
Montes, Antonio
Roca, Gisela
Sabate, Sergi
Lao, José Ignacio
Navarro, Arcadi
Cantillo, Jordi
Canet, Jaume
GENDOLCAT Study Group
format artículo
author Montes, Antonio
Roca, Gisela
Sabate, Sergi
Lao, José Ignacio
Navarro, Arcadi
Cantillo, Jordi
Canet, Jaume
GENDOLCAT Study Group
spellingShingle Montes, Antonio
Roca, Gisela
Sabate, Sergi
Lao, José Ignacio
Navarro, Arcadi
Cantillo, Jordi
Canet, Jaume
GENDOLCAT Study Group
Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study
author_sort Montes, Antonio
title Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study
title_short Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study
title_full Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study
title_fullStr Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study
title_full_unstemmed Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study
title_sort genetic and clinical factors associated with chronic postsurgical pain after hernia repair, hysterectomy, and thoracotomy: a two-year multicenter cohort study
publisher Lippincott Williams & Wilkins
publishDate 2015-05
url http://hdl.handle.net/10261/151595
http://dx.doi.org/10.13039/100008666
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