The MEKRE93 (Methoprene tolerant-Krüppel homolog 1-E93) pathway in the regulation of insect metamorphosis, and the homology of the pupal stage
Recent studies on transcription factor E93 revealed that it triggers adult morphogenesis in Blattella germanica, Tribolium castaneum and Drosophila melanogaster. Moreover, we show here that Krüppel homolog 1 (Kr-h1), a transducer of the antimetamorphic action of juvenile hormone (JH), represses E93 expression. Kr-h1 is upstream of E93, and upstream of Kr-h1 is Methoprene-tolerant (Met), the latter being the JH receptor in hemimetabolan and holometabolan species. As such, the Met - Kr-h1 - E93 pathway (hereinafter named >MEKRE93 pathway>) appears to be central to the status quo action of JH, which switch adult morphogenesis off and on in species ranging from cockroaches to flies. The decrease in Kr-h1 mRNA and the rise of E93 expression that triggers adult morphogenesis occur at the beginning of the last instar nymph or in the prepupae of hemimetabolan and holometabolan species, respectively. This suggests that the hemimetabolan last nymph (considering the entire stage, from the apolysis to the last instar until the next apolysis that gives rise to the adult) is ontogenetically homologous to the holometabolan pupa (also considered between two apolyses, thus comprising the prepupal stage). © 2014 Elsevier Ltd.
Main Authors: | Bellés, Xavier, Santos, Carolina G. |
---|---|
Other Authors: | Ministerio de Ciencia e Innovación (España) |
Format: | artículo biblioteca |
Published: |
Elsevier
2014-09
|
Subjects: | Krüppel homolog 1, Methoprene tolerant, E93, Broad complex, Ecdysone, Juvenile hormone, Insect metamorphosis, |
Online Access: | http://hdl.handle.net/10261/115736 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100002425 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Krüppel homolog 1 and E93: The doorkeeper and the key to insect metamorphosis
by: Bellés, Xavier
Published: (2020-03) -
Upregulation of E93 gene expression acts as the trigger for metamorphosis independently of the threshold Size in the Beetle Tribolium castaneum
by: Chafino, Silvia, et al.
Published: (2019-04-23) -
CREB-binding protein contributes to the regulation of endocrine and developmental pathways in insect hemimetabolan pre-metamorphosis
by: Fernández-Nicolas, Ana, et al.
Published: (2016-03) -
E93-depleted adult insects preserve the prothoracic gland and molt again
by: Kamsoi, Orathai, et al.
Published: (2020-11-27) -
MicroRNAs and the Evolution of Insect Metamorphosis
by: Bellés, Xavier
Published: (2017-01)