The MEKRE93 (Methoprene tolerant-Krüppel homolog 1-E93) pathway in the regulation of insect metamorphosis, and the homology of the pupal stage
Recent studies on transcription factor E93 revealed that it triggers adult morphogenesis in Blattella germanica, Tribolium castaneum and Drosophila melanogaster. Moreover, we show here that Krüppel homolog 1 (Kr-h1), a transducer of the antimetamorphic action of juvenile hormone (JH), represses E93 expression. Kr-h1 is upstream of E93, and upstream of Kr-h1 is Methoprene-tolerant (Met), the latter being the JH receptor in hemimetabolan and holometabolan species. As such, the Met - Kr-h1 - E93 pathway (hereinafter named >MEKRE93 pathway>) appears to be central to the status quo action of JH, which switch adult morphogenesis off and on in species ranging from cockroaches to flies. The decrease in Kr-h1 mRNA and the rise of E93 expression that triggers adult morphogenesis occur at the beginning of the last instar nymph or in the prepupae of hemimetabolan and holometabolan species, respectively. This suggests that the hemimetabolan last nymph (considering the entire stage, from the apolysis to the last instar until the next apolysis that gives rise to the adult) is ontogenetically homologous to the holometabolan pupa (also considered between two apolyses, thus comprising the prepupal stage). © 2014 Elsevier Ltd.
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Format: | artículo biblioteca |
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Elsevier
2014-09
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Subjects: | Krüppel homolog 1, Methoprene tolerant, E93, Broad complex, Ecdysone, Juvenile hormone, Insect metamorphosis, |
Online Access: | http://hdl.handle.net/10261/115736 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100002425 |
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dig-ibe-es-10261-1157362017-10-10T12:25:48Z The MEKRE93 (Methoprene tolerant-Krüppel homolog 1-E93) pathway in the regulation of insect metamorphosis, and the homology of the pupal stage Bellés, Xavier Santos, Carolina G. Ministerio de Ciencia e Innovación (España) Ministerio de Economía y Competitividad (España) Consejo Superior de Investigaciones Científicas (España) Governo Brasil Krüppel homolog 1 Methoprene tolerant E93 Broad complex Ecdysone Juvenile hormone Insect metamorphosis Recent studies on transcription factor E93 revealed that it triggers adult morphogenesis in Blattella germanica, Tribolium castaneum and Drosophila melanogaster. Moreover, we show here that Krüppel homolog 1 (Kr-h1), a transducer of the antimetamorphic action of juvenile hormone (JH), represses E93 expression. Kr-h1 is upstream of E93, and upstream of Kr-h1 is Methoprene-tolerant (Met), the latter being the JH receptor in hemimetabolan and holometabolan species. As such, the Met - Kr-h1 - E93 pathway (hereinafter named >MEKRE93 pathway>) appears to be central to the status quo action of JH, which switch adult morphogenesis off and on in species ranging from cockroaches to flies. The decrease in Kr-h1 mRNA and the rise of E93 expression that triggers adult morphogenesis occur at the beginning of the last instar nymph or in the prepupae of hemimetabolan and holometabolan species, respectively. This suggests that the hemimetabolan last nymph (considering the entire stage, from the apolysis to the last instar until the next apolysis that gives rise to the adult) is ontogenetically homologous to the holometabolan pupa (also considered between two apolyses, thus comprising the prepupal stage). © 2014 Elsevier Ltd. Support for the original research included in this work was provided by the Spanish MICINN (grant CGL2008-03517/BOS to XB) and MINECO (grant CGL2012-36251 to XB) and by the CSIC (grant 2010TW0019, from the Formosa program, to XB). CGS received a Grant from Brazil Government (Processo CNPQ, 24574812012-L) to work in the Institute of Evolutionary Biology in Barcelona. Peer Reviewed 2015-05-26T06:36:18Z 2015-05-26T06:36:18Z 2014-09 2015-05-26T06:36:18Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1016/j.ibmb.2014.06.009 issn: 0965-1748 Insect Biochemistry and Molecular Biology 52: 60-68 (2014) http://hdl.handle.net/10261/115736 10.1016/j.ibmb.2014.06.009 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100002425 http://dx.doi.org/10.1016/j.ibmb.2014.06.009 Sí none Elsevier |
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Krüppel homolog 1 Methoprene tolerant E93 Broad complex Ecdysone Juvenile hormone Insect metamorphosis Krüppel homolog 1 Methoprene tolerant E93 Broad complex Ecdysone Juvenile hormone Insect metamorphosis |
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Krüppel homolog 1 Methoprene tolerant E93 Broad complex Ecdysone Juvenile hormone Insect metamorphosis Krüppel homolog 1 Methoprene tolerant E93 Broad complex Ecdysone Juvenile hormone Insect metamorphosis Bellés, Xavier Santos, Carolina G. The MEKRE93 (Methoprene tolerant-Krüppel homolog 1-E93) pathway in the regulation of insect metamorphosis, and the homology of the pupal stage |
description |
Recent studies on transcription factor E93 revealed that it triggers adult morphogenesis in Blattella germanica, Tribolium castaneum and Drosophila melanogaster. Moreover, we show here that Krüppel homolog 1 (Kr-h1), a transducer of the antimetamorphic action of juvenile hormone (JH), represses E93 expression. Kr-h1 is upstream of E93, and upstream of Kr-h1 is Methoprene-tolerant (Met), the latter being the JH receptor in hemimetabolan and holometabolan species. As such, the Met - Kr-h1 - E93 pathway (hereinafter named >MEKRE93 pathway>) appears to be central to the status quo action of JH, which switch adult morphogenesis off and on in species ranging from cockroaches to flies. The decrease in Kr-h1 mRNA and the rise of E93 expression that triggers adult morphogenesis occur at the beginning of the last instar nymph or in the prepupae of hemimetabolan and holometabolan species, respectively. This suggests that the hemimetabolan last nymph (considering the entire stage, from the apolysis to the last instar until the next apolysis that gives rise to the adult) is ontogenetically homologous to the holometabolan pupa (also considered between two apolyses, thus comprising the prepupal stage). © 2014 Elsevier Ltd. |
author2 |
Ministerio de Ciencia e Innovación (España) |
author_facet |
Ministerio de Ciencia e Innovación (España) Bellés, Xavier Santos, Carolina G. |
format |
artículo |
topic_facet |
Krüppel homolog 1 Methoprene tolerant E93 Broad complex Ecdysone Juvenile hormone Insect metamorphosis |
author |
Bellés, Xavier Santos, Carolina G. |
author_sort |
Bellés, Xavier |
title |
The MEKRE93 (Methoprene tolerant-Krüppel homolog 1-E93) pathway in the regulation of insect metamorphosis, and the homology of the pupal stage |
title_short |
The MEKRE93 (Methoprene tolerant-Krüppel homolog 1-E93) pathway in the regulation of insect metamorphosis, and the homology of the pupal stage |
title_full |
The MEKRE93 (Methoprene tolerant-Krüppel homolog 1-E93) pathway in the regulation of insect metamorphosis, and the homology of the pupal stage |
title_fullStr |
The MEKRE93 (Methoprene tolerant-Krüppel homolog 1-E93) pathway in the regulation of insect metamorphosis, and the homology of the pupal stage |
title_full_unstemmed |
The MEKRE93 (Methoprene tolerant-Krüppel homolog 1-E93) pathway in the regulation of insect metamorphosis, and the homology of the pupal stage |
title_sort |
mekre93 (methoprene tolerant-krüppel homolog 1-e93) pathway in the regulation of insect metamorphosis, and the homology of the pupal stage |
publisher |
Elsevier |
publishDate |
2014-09 |
url |
http://hdl.handle.net/10261/115736 http://dx.doi.org/10.13039/501100004837 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100003339 http://dx.doi.org/10.13039/501100002425 |
work_keys_str_mv |
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