A genome-wide survey does not show the genetic distinctiveness of Basques
Basques are a cultural isolate, and, according to mainly allele frequencies of classical polymorphisms, also a genetic isolate. We investigated the differentiation of Spanish Basques from the rest of Iberian populations by means of a dense, genome-wide SNP array. We found that F ST distances between Spanish Basques and other populations were similar to those between pairs of non-Basque populations. The same result is found in a PCA of individuals, showing a general distinction between Iberians and other South Europeans independently of being Basques. Pathogen-mediated natural selection may be responsible for the high differentiation previously reported for Basques at very specific genes such as ABO, RH, and HLA. Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised. © 2010 Springer-Verlag.
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dig-ibe-es-10261-1113492018-09-27T07:09:36Z A genome-wide survey does not show the genetic distinctiveness of Basques Laayouni, Hafid Calafell, Francesc Bertranpetit, Jaume Generalitat de Catalunya Fundación Genoma España Ministerio de Ciencia y Tecnología (España) Basques are a cultural isolate, and, according to mainly allele frequencies of classical polymorphisms, also a genetic isolate. We investigated the differentiation of Spanish Basques from the rest of Iberian populations by means of a dense, genome-wide SNP array. We found that F ST distances between Spanish Basques and other populations were similar to those between pairs of non-Basque populations. The same result is found in a PCA of individuals, showing a general distinction between Iberians and other South Europeans independently of being Basques. Pathogen-mediated natural selection may be responsible for the high differentiation previously reported for Basques at very specific genes such as ABO, RH, and HLA. Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised. © 2010 Springer-Verlag. This research was supported by Genoma España (Proyecto Piloto CeGen), Dirección General de Investigación, Ministerio de Ciencia y Tecnología, Spain (grants SAF2007-63171, BFU2007-63657) and Direcció General de Recerca, Generalitat de Catalunya (2005SGR00608). Peer Reviewed 2015-02-26T11:13:51Z 2015-02-26T11:13:51Z 2010-04 2015-02-26T11:13:51Z artículo http://purl.org/coar/resource_type/c_6501 doi: 10.1007/s00439-010-0798-3 issn: 0340-6717 e-issn: 1432-1203 Human Genetics 127(4): 455-458 (2010) http://hdl.handle.net/10261/111349 10.1007/s00439-010-0798-3 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100006280 http://dx.doi.org/10.1007/s00439-010-0798-3 Sí none Springer |
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Basques are a cultural isolate, and, according to mainly allele frequencies of classical polymorphisms, also a genetic isolate. We investigated the differentiation of Spanish Basques from the rest of Iberian populations by means of a dense, genome-wide SNP array. We found that F ST distances between Spanish Basques and other populations were similar to those between pairs of non-Basque populations. The same result is found in a PCA of individuals, showing a general distinction between Iberians and other South Europeans independently of being Basques. Pathogen-mediated natural selection may be responsible for the high differentiation previously reported for Basques at very specific genes such as ABO, RH, and HLA. Thus, Basques cannot be considered a genetic outlier under a general genome scope and interpretations on their origin may have to be revised. © 2010 Springer-Verlag. |
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Generalitat de Catalunya |
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Generalitat de Catalunya Laayouni, Hafid Calafell, Francesc Bertranpetit, Jaume |
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Laayouni, Hafid Calafell, Francesc Bertranpetit, Jaume |
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Laayouni, Hafid Calafell, Francesc Bertranpetit, Jaume A genome-wide survey does not show the genetic distinctiveness of Basques |
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Laayouni, Hafid |
title |
A genome-wide survey does not show the genetic distinctiveness of Basques |
title_short |
A genome-wide survey does not show the genetic distinctiveness of Basques |
title_full |
A genome-wide survey does not show the genetic distinctiveness of Basques |
title_fullStr |
A genome-wide survey does not show the genetic distinctiveness of Basques |
title_full_unstemmed |
A genome-wide survey does not show the genetic distinctiveness of Basques |
title_sort |
genome-wide survey does not show the genetic distinctiveness of basques |
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Springer |
publishDate |
2010-04 |
url |
http://hdl.handle.net/10261/111349 http://dx.doi.org/10.13039/501100002809 http://dx.doi.org/10.13039/501100006280 |
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