Gut Microbiota and Derived Short-Chain Fatty Acids Are Linked to Evolution of Heart Failure Patients
There is a lack of direct evidence regarding gut microbiota dysbiosis and changes in short-chain fatty acids (SCFAs) in heart failure (HF) patients. We sought to assess any association between gut microbiota composition, SCFA production, clinical parameters, and the inflammatory profile in a cohort of newly diagnosed HF patients. In this longitudinal prospective study, we enrolled eighteen newly diagnosed HF patients. At admission and after 12 months, blood samples were collected for the assessment of proinflammatory cytokines, monocyte populations, and endothelial dysfunction, and stool samples were collected for analysis of gut microbiota composition and quantification of SCFAs. Twelve months after the initial HF episode, patients demonstrated improved clinical parameters and reduced inflammatory state and endothelial dysfunction. This favorable evolution was associated with a reversal of microbiota dysbiosis, consisting of the increment of health-related bacteria, such as genus Bifidobacterium, and levels of SCFAs, mainly butyrate. Furthermore, there was a decrease in the abundance of pathogenic bacteria. In vitro, fecal samples collected after 12 months of follow-up exhibited lower inflammation than samples collected at admission. In conclusion, the favorable progression of HF patients after the initial episode was linked to the reversal of gut microbiota dysbiosis and increased SCFA production, particularly butyrate. Whether restoring butyrate levels or promoting the growth of butyrate-producing bacteria could serve as a complementary treatment for these patients deserves further studies.
Main Authors: | Modrego, Javier, Ortega Hernández, Adriana, Goirigolzarri, Josebe, Restrepo Córdoba, María Alejandra, Bäuerl, Christine, Cortés Macías, Erika, Sánchez González, Silvia, Estéban Fernández, Alberto, Pérez Villacastín, Julián, Collado, María Carmen, Gómez Garre, Dulcenombre |
---|---|
Other Authors: | Instituto de Salud Carlos III |
Format: | artículo biblioteca |
Language: | English |
Published: |
Multidisciplinary Digital Publishing Institute
2023-09-09
|
Subjects: | Endothelial dysfunction, Gut microbiota, Heart failure, Inflammation, Short chain fatty acids, |
Online Access: | http://hdl.handle.net/10261/338477 http://dx.doi.org/10.13039/501100004587 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/100009664 https://api.elsevier.com/content/abstract/scopus_id/85172766602 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Shifting pattern of gut microbiota in pregnant women two decades apart - an observational study
by: Rautava, Samuli, et al.
Published: (2023-07-19) -
Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota
by: Fusco, William, et al.
Published: (2023-05-06) -
Digestion by saliva, simulated gastric and small intestinal juices and in vitro fermentation by human gut microbiota of polysaccharides from cicer Arietinum L. hulls
by: Akhtar, Hafiz Muhammad Saleem, et al.
Published: (2021) -
In vitro fermentation of lactulose-derived oligosaccharides by mixed fecal microbiota
by: Cardelle-Cobas, Alejandra, et al.
Published: (2012) -
Association of Inflammatory Biomarkers with the Gut Microbiota and Short-Chain Fatty Acids in Prediabetic Subjects
by: Díaz-Prieto, Ligia E., et al.
Published: (2024-02)