Maternal-infant antibiotic resistance genes transference: what do we know?
Resistance to antibiotics is becoming a worldwide threat as infections caused by multidrug-resistant pathogenic microorganisms can overcome antibiotic treatments and spread quickly in the population. In the context of early life, newborns are at increased risk as their immune system is still under development, so infections and acquisition of resistance during childhood have short- and long-term consequences for the health. The moment of birth is the first exposure of infants to possible antibiotic-resistant microorganisms that may colonize their gut and other body sites. Different factors including mode of delivery, previous antibiotic exposure of the mother, gestational age and consumption of antibiotics in early-life have been described to modulate the neonate's microbiota, and thus, the resistome. Other factors, such as lactation, also impact the establishment and development of gut microbiota, but little is known about the role of breastmilk in transferring Antibiotic Resistant Genes (ARG). A deeper understanding of vertical transmission of antibiotic resistance from mothers to their offspring is necessary to determine the most effective strategies for reducing antibiotic resistance in the early life. In this review, we aim to present the current perspective on antibiotic resistances in mother-infant dyads, as well as a new insight on the study of the human gut and breastmilk resistome, and current strategies to overcome this public health problem, toward highlighting the gaps of knowledge that still need to be closed.
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Taylor & Francis
2023-04-05
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Subjects: | Antibiotics, Breastmilk, Gut, Infant, Microbiota, Mother, Pregnancy, Resistome, http://metadata.un.org/sdg/3, Ensure healthy lives and promote well-being for all at all ages, |
Online Access: | http://hdl.handle.net/10261/308214 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003359 https://api.elsevier.com/content/abstract/scopus_id/85151778142 |
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dig-iata-es-10261-3082142024-05-15T20:46:00Z Maternal-infant antibiotic resistance genes transference: what do we know? Samarra, Anna Esteban Torres, María Cabrera-Rubio, Raúl Bernabeu, Manuel Arboleya, Silvia Gueimonde Fernández, Miguel Collado, María Carmen Agencia Estatal de Investigación (España) Generalitat Valenciana European Commission 0000-0001-7846-2078 0000-0001-8433-5729 0000-0003-3652-9558 0000-0002-3011-5373 0000-0002-6155-5822 0000-0002-0192-901X 0000-0002-6204-4864 Antibiotics Breastmilk Gut Infant Microbiota Mother Pregnancy Resistome http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages Resistance to antibiotics is becoming a worldwide threat as infections caused by multidrug-resistant pathogenic microorganisms can overcome antibiotic treatments and spread quickly in the population. In the context of early life, newborns are at increased risk as their immune system is still under development, so infections and acquisition of resistance during childhood have short- and long-term consequences for the health. The moment of birth is the first exposure of infants to possible antibiotic-resistant microorganisms that may colonize their gut and other body sites. Different factors including mode of delivery, previous antibiotic exposure of the mother, gestational age and consumption of antibiotics in early-life have been described to modulate the neonate's microbiota, and thus, the resistome. Other factors, such as lactation, also impact the establishment and development of gut microbiota, but little is known about the role of breastmilk in transferring Antibiotic Resistant Genes (ARG). A deeper understanding of vertical transmission of antibiotic resistance from mothers to their offspring is necessary to determine the most effective strategies for reducing antibiotic resistance in the early life. In this review, we aim to present the current perspective on antibiotic resistances in mother-infant dyads, as well as a new insight on the study of the human gut and breastmilk resistome, and current strategies to overcome this public health problem, toward highlighting the gaps of knowledge that still need to be closed. We acknowledge Generalitat Valenciana-European Social Fund (ACIF/2021) for the predoctoral fellowship grant to Anna Samarra. Manuel Bernabeu wishes to thank the Post-PhD Program of University of Barcelona for the requalification of the Spanish University System from the Ministry of Universities of the Government of Spain, modality “Margarita Salas”, financed by the European Union, Next Generation EU. Maria Esteban-Torres thanks the support received from the MSCA-IF postdoctoral grant (MicroMi-898088). Raul Cabrera-Rubio wishes to thank Generalitat-Valenciana for the grant Plan GenT project (CDEIGENT 2020). Finally, authors also acknowledge support of Institute of Agrochemistry and Food Technology (IATA-CSIC). IATA-CSIC is a Centre of Excellence Severo Ochoa (CEX2021-001189-S MCIN/AEI/10.13039/501100011033). Peer reviewed 2023-05-04T11:33:00Z 2023-05-04T11:33:00Z 2023-04-05 artículo de revisión http://purl.org/coar/resource_type/c_dcae04bc Gut microbes 15(1): 2194797 (2023) 1949-0976 CEX2021-001189-S http://hdl.handle.net/10261/308214 10.1080/19490976.2023.2194797 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003359 37020319 2-s2.0-85151778142 https://api.elsevier.com/content/abstract/scopus_id/85151778142 en #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/H2020/898088 info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2020-2023/CEX2021-001189-S Gut microbes Publisher's version The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1080/19490976.2023.2194797 https://doi.org/10.1080/19490976.2023.2194797 Sí open application/pdf Taylor & Francis |
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Antibiotics Breastmilk Gut Infant Microbiota Mother Pregnancy Resistome http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages Antibiotics Breastmilk Gut Infant Microbiota Mother Pregnancy Resistome http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages |
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Antibiotics Breastmilk Gut Infant Microbiota Mother Pregnancy Resistome http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages Antibiotics Breastmilk Gut Infant Microbiota Mother Pregnancy Resistome http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages Samarra, Anna Esteban Torres, María Cabrera-Rubio, Raúl Bernabeu, Manuel Arboleya, Silvia Gueimonde Fernández, Miguel Collado, María Carmen Maternal-infant antibiotic resistance genes transference: what do we know? |
description |
Resistance to antibiotics is becoming a worldwide threat as infections caused by multidrug-resistant pathogenic microorganisms can overcome antibiotic treatments and spread quickly in the population. In the context of early life, newborns are at increased risk as their immune system is still under development, so infections and acquisition of resistance during childhood have short- and long-term consequences for the health. The moment of birth is the first exposure of infants to possible antibiotic-resistant microorganisms that may colonize their gut and other body sites. Different factors including mode of delivery, previous antibiotic exposure of the mother, gestational age and consumption of antibiotics in early-life have been described to modulate the neonate's microbiota, and thus, the resistome. Other factors, such as lactation, also impact the establishment and development of gut microbiota, but little is known about the role of breastmilk in transferring Antibiotic Resistant Genes (ARG). A deeper understanding of vertical transmission of antibiotic resistance from mothers to their offspring is necessary to determine the most effective strategies for reducing antibiotic resistance in the early life. In this review, we aim to present the current perspective on antibiotic resistances in mother-infant dyads, as well as a new insight on the study of the human gut and breastmilk resistome, and current strategies to overcome this public health problem, toward highlighting the gaps of knowledge that still need to be closed. |
author2 |
Agencia Estatal de Investigación (España) |
author_facet |
Agencia Estatal de Investigación (España) Samarra, Anna Esteban Torres, María Cabrera-Rubio, Raúl Bernabeu, Manuel Arboleya, Silvia Gueimonde Fernández, Miguel Collado, María Carmen |
format |
artículo de revisión |
topic_facet |
Antibiotics Breastmilk Gut Infant Microbiota Mother Pregnancy Resistome http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages |
author |
Samarra, Anna Esteban Torres, María Cabrera-Rubio, Raúl Bernabeu, Manuel Arboleya, Silvia Gueimonde Fernández, Miguel Collado, María Carmen |
author_sort |
Samarra, Anna |
title |
Maternal-infant antibiotic resistance genes transference: what do we know? |
title_short |
Maternal-infant antibiotic resistance genes transference: what do we know? |
title_full |
Maternal-infant antibiotic resistance genes transference: what do we know? |
title_fullStr |
Maternal-infant antibiotic resistance genes transference: what do we know? |
title_full_unstemmed |
Maternal-infant antibiotic resistance genes transference: what do we know? |
title_sort |
maternal-infant antibiotic resistance genes transference: what do we know? |
publisher |
Taylor & Francis |
publishDate |
2023-04-05 |
url |
http://hdl.handle.net/10261/308214 http://dx.doi.org/10.13039/501100011033 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003359 https://api.elsevier.com/content/abstract/scopus_id/85151778142 |
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