Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men

Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men

This is the peer reviewed version of the following article: Benítez‐Páez, A., Hess, A. L., Krautbauer, S., Liebisch, G., Christensen, L., Hjorth, M. F., Larsen, T. M., Sanz, Y., Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men. Mol. Nutr. Food Res. 2021, 65, 2000996, which has been published in final form at https://doi.org/10.1002/mnfr.202000996. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

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Main Authors: Benítez-Páez, Alfonso, Hess, A.L., Krautbauer, S., Liebisch, G., Christensen, L., Hjorth, M.F., Larsen, T.M., Sanz Herranz, Yolanda
Other Authors: European Commission
Format: artículo biblioteca
Language:English
Published: John Wiley & Sons 2021-02-24
Subjects:Dietary fiber, Gut microbiome, Inulin, Metabolomics, Multi‐omics, Obesity, Resistant maltodextrin, Weight loss,
Online Access:http://hdl.handle.net/10261/240110
http://dx.doi.org/10.13039/501100000780
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spelling dig-iata-es-10261-2401102022-02-24T05:30:30Z Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men Benítez-Páez, Alfonso Hess, A.L. Krautbauer, S. Liebisch, G. Christensen, L. Hjorth, M.F. Larsen, T.M. Sanz Herranz, Yolanda European Commission Dietary fiber Gut microbiome Inulin Metabolomics Multi‐omics Obesity Resistant maltodextrin Weight loss This is the peer reviewed version of the following article: Benítez‐Páez, A., Hess, A. L., Krautbauer, S., Liebisch, G., Christensen, L., Hjorth, M. F., Larsen, T. M., Sanz, Y., Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men. Mol. Nutr. Food Res. 2021, 65, 2000996, which has been published in final form at https://doi.org/10.1002/mnfr.202000996. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Scope: Dietary‐based strategies are regularly explored in controlled clinical trials to provide cost‐effective therapies to tackle obesity and its comorbidities. The article presents a complementary analysis based on a multivariate multi‐omics approach of a caloric restriction intervention (CRD) with fiber supplementation to unveil synergic effects on body weight control, lipid metabolism, and gut microbiota. Methods and results: The study explores fecal bile acids (BAs) and short‐chain fatty acids (SCFAs), plasma BAs, and fecal shotgun metagenomics on 80 overweight participants of a 12‐week caloric restriction clinical trial (−500 kcal day−1) randomly allocated into fiber (10 g day−1 inulin + 10 g day−1 resistant maltodextrin) or placebo (maltodextrin) supplementation groups. The multi‐omic data integration analysis uncovered the benefits of the fiber supplementation and/or the CRD (e.g., increase of Parabacteroides distasonis and fecal propionate), showing sex‐specific effects on either adiposity and fasting insulin; effects thought to be linked to changes of specific gut microbiota species, functional genes, and bacterially produced metabolites like SCFAs and secondary BAs. Conclusions: This study identifies diet‐microbe‐host interactions helping to design personalised interventions. It also suggests that sex perspective should be considered routinely in future studies on dietary interventions efficacy. All in all, the study uncovers that the dietary intervention is more beneficial for women than men. This study was fully funded by the European Commission 7th Framework Programme through the MyNewGut project (Grant agreement No. 613979). Peer reviewed 2021-05-07T05:04:02Z 2021-05-07T05:04:02Z 2021-02-24 artículo http://purl.org/coar/resource_type/c_6501 Molecular Nutrition and Food Research 65 (8): 2000996 (2021) 1613-4125 http://hdl.handle.net/10261/240110 10.1002/mnfr.202000996 http://dx.doi.org/10.13039/501100000780 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/EC/FP7/613979 Postprint https://doi.org/10.1002/mnfr.202000996 Sí open John Wiley & Sons
institution IATA ES
collection DSpace
country España
countrycode ES
component Bibliográfico
access En linea
databasecode dig-iata-es
tag biblioteca
region Europa del Sur
libraryname Biblioteca del IATA España
language English
topic Dietary fiber
Gut microbiome
Inulin
Metabolomics
Multi‐omics
Obesity
Resistant maltodextrin
Weight loss
Dietary fiber
Gut microbiome
Inulin
Metabolomics
Multi‐omics
Obesity
Resistant maltodextrin
Weight loss
spellingShingle Dietary fiber
Gut microbiome
Inulin
Metabolomics
Multi‐omics
Obesity
Resistant maltodextrin
Weight loss
Dietary fiber
Gut microbiome
Inulin
Metabolomics
Multi‐omics
Obesity
Resistant maltodextrin
Weight loss
Benítez-Páez, Alfonso
Hess, A.L.
Krautbauer, S.
Liebisch, G.
Christensen, L.
Hjorth, M.F.
Larsen, T.M.
Sanz Herranz, Yolanda
Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men
description This is the peer reviewed version of the following article: Benítez‐Páez, A., Hess, A. L., Krautbauer, S., Liebisch, G., Christensen, L., Hjorth, M. F., Larsen, T. M., Sanz, Y., Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men. Mol. Nutr. Food Res. 2021, 65, 2000996, which has been published in final form at https://doi.org/10.1002/mnfr.202000996. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
author2 European Commission
author_facet European Commission
Benítez-Páez, Alfonso
Hess, A.L.
Krautbauer, S.
Liebisch, G.
Christensen, L.
Hjorth, M.F.
Larsen, T.M.
Sanz Herranz, Yolanda
format artículo
topic_facet Dietary fiber
Gut microbiome
Inulin
Metabolomics
Multi‐omics
Obesity
Resistant maltodextrin
Weight loss
author Benítez-Páez, Alfonso
Hess, A.L.
Krautbauer, S.
Liebisch, G.
Christensen, L.
Hjorth, M.F.
Larsen, T.M.
Sanz Herranz, Yolanda
author_sort Benítez-Páez, Alfonso
title Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men
title_short Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men
title_full Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men
title_fullStr Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men
title_full_unstemmed Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men
title_sort sex, food, and the gut microbiota: disparate response to caloric restriction diet with fiber supplementation in women and men
publisher John Wiley & Sons
publishDate 2021-02-24
url http://hdl.handle.net/10261/240110
http://dx.doi.org/10.13039/501100000780
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