Effect of probiotics in prevention of atopic dermatitis is dependent on the intrinsic microbiota at early infancy
Although a link between probiotic intervention and reduction in atopic disease has been documented, no consistent associations with microbiota has yet been established. Here we have conducted an extensive analysis of the microbiota from more than 250 mother child pairs from a probiotic intervention cohort, where we previously have shown 40 % reduction in atopic dermatitis. Within the probiotic intervention group at the age of 10 days we found that the atopic children had a deviating microbiota (p = 0.028, BH-FDR corrected Kruskal Wallis) with high levels (> 10 %) of a bacterium related to Bifidobacterium dentium (p=0.039, BHFDR corrected Chi-square). Based on these findings, we propose a model with two groups of children where the group responding to probiotic intervention, has gut microbiota related to that of non-atopic children; while the non-responding group has a divergent microbiota at the age of 10 days with overrepresented amounts of B. dentium. In conclusion, our results support the importance of early colonization for prevention of diseases developing later in life, with potential intervention effects being dependent on the intrinsic microbiota.
| Main Authors: | , , , , , , , , , |
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| Format: | carta al director biblioteca |
| Language: | English |
| Published: |
Elsevier
2016-12-05
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| Subjects: | Probiotics, Atopy, Gut microbiota, Infancy, Intervention, |
| Online Access: | http://hdl.handle.net/10261/204103 |
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