A quantitative theory for genomic offset statistics
Genomic offset statistics predict the maladaptation of populations to rapid habitat alteration based on association of genotypes with environmental variation. Despite substantial evidence for empirical validity, genomic offset statistics have well-identified limitations, and lack a theory that would facilitate interpretations of predicted values. Here, we clarified the theoretical relationships between genomic offset statistics and unobserved fitness traits controlled by environmentally selected loci and proposed a geometric measure to predict fitness after rapid change in local environment. The predictions of our theory were verified in computer simulations and in empirical data on African pearl millet (Cenchrus americanus) obtained from a common garden experiment. Our results proposed a unified perspective on genomic offset statistics and provided a theoretical foundation necessary when considering their potential application in conservation management in the face of environmental change.
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Subjects: | F30 - Génétique et amélioration des plantes, U10 - Informatique, mathématiques et statistiques, génomique, statistiques, génétique quantitative, analyse quantitative, Cenchrus americanus, http://aims.fao.org/aos/agrovoc/c_92382, http://aims.fao.org/aos/agrovoc/c_49978, http://aims.fao.org/aos/agrovoc/c_34327, http://aims.fao.org/aos/agrovoc/c_32660, http://aims.fao.org/aos/agrovoc/c_13199, |
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dig-cirad-fr-6058752024-01-29T12:29:10Z http://agritrop.cirad.fr/605875/ http://agritrop.cirad.fr/605875/ A quantitative theory for genomic offset statistics. Gain Clément, Rhone Bénédicte, Cubry Philippe, Salazar Israfel, Forbes Florence, Vigouroux Yves, Jay Flora, François Olivier. 2023. Molecular Biology and Evolution, 40 (6):msad140, 10 p.https://doi.org/10.1093/molbev/msad140 <https://doi.org/10.1093/molbev/msad140> A quantitative theory for genomic offset statistics Gain, Clément Rhone, Bénédicte Cubry, Philippe Salazar, Israfel Forbes, Florence Vigouroux, Yves Jay, Flora François, Olivier eng 2023 Molecular Biology and Evolution F30 - Génétique et amélioration des plantes U10 - Informatique, mathématiques et statistiques génomique statistiques génétique quantitative analyse quantitative Cenchrus americanus http://aims.fao.org/aos/agrovoc/c_92382 http://aims.fao.org/aos/agrovoc/c_49978 http://aims.fao.org/aos/agrovoc/c_34327 http://aims.fao.org/aos/agrovoc/c_32660 http://aims.fao.org/aos/agrovoc/c_13199 Genomic offset statistics predict the maladaptation of populations to rapid habitat alteration based on association of genotypes with environmental variation. Despite substantial evidence for empirical validity, genomic offset statistics have well-identified limitations, and lack a theory that would facilitate interpretations of predicted values. Here, we clarified the theoretical relationships between genomic offset statistics and unobserved fitness traits controlled by environmentally selected loci and proposed a geometric measure to predict fitness after rapid change in local environment. The predictions of our theory were verified in computer simulations and in empirical data on African pearl millet (Cenchrus americanus) obtained from a common garden experiment. Our results proposed a unified perspective on genomic offset statistics and provided a theoretical foundation necessary when considering their potential application in conservation management in the face of environmental change. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/605875/1/2023_Gain-etal_MBE_A%20quantitative%20theory%20for%20genomic%20offset%20statistics.pdf text cc_by_nc info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/4.0/ https://doi.org/10.1093/molbev/msad140 10.1093/molbev/msad140 info:eu-repo/semantics/altIdentifier/doi/10.1093/molbev/msad140 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1093/molbev/msad140 info:eu-repo/semantics/reference/purl/https://github.com/bcm-uga/geneticgap info:eu-repo/semantics/reference/purl/https://github.com/bcm-uga/LEA info:eu-repo/grantAgreement///ANR-22-CE45-0033//(FRA) Modèles pour l'écologie génomique prédictive/PEG2 info:eu-repo/grantAgreement///ANR-22-CE32-0008//(FRA) Genomic prediction of vulnerability of African crops to future climate/AfrADAPT info:eu-repo/grantAgreement///ANR-18-CE36-0005//(FRA) Exposition prénatale au tabac et à la pollution atmosphérique et effets sur la santé respiratoire et le neurodévelopment de l'enfant: rôle de la méthylation placentaire/ETAPE |
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F30 - Génétique et amélioration des plantes U10 - Informatique, mathématiques et statistiques génomique statistiques génétique quantitative analyse quantitative Cenchrus americanus http://aims.fao.org/aos/agrovoc/c_92382 http://aims.fao.org/aos/agrovoc/c_49978 http://aims.fao.org/aos/agrovoc/c_34327 http://aims.fao.org/aos/agrovoc/c_32660 http://aims.fao.org/aos/agrovoc/c_13199 F30 - Génétique et amélioration des plantes U10 - Informatique, mathématiques et statistiques génomique statistiques génétique quantitative analyse quantitative Cenchrus americanus http://aims.fao.org/aos/agrovoc/c_92382 http://aims.fao.org/aos/agrovoc/c_49978 http://aims.fao.org/aos/agrovoc/c_34327 http://aims.fao.org/aos/agrovoc/c_32660 http://aims.fao.org/aos/agrovoc/c_13199 |
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F30 - Génétique et amélioration des plantes U10 - Informatique, mathématiques et statistiques génomique statistiques génétique quantitative analyse quantitative Cenchrus americanus http://aims.fao.org/aos/agrovoc/c_92382 http://aims.fao.org/aos/agrovoc/c_49978 http://aims.fao.org/aos/agrovoc/c_34327 http://aims.fao.org/aos/agrovoc/c_32660 http://aims.fao.org/aos/agrovoc/c_13199 F30 - Génétique et amélioration des plantes U10 - Informatique, mathématiques et statistiques génomique statistiques génétique quantitative analyse quantitative Cenchrus americanus http://aims.fao.org/aos/agrovoc/c_92382 http://aims.fao.org/aos/agrovoc/c_49978 http://aims.fao.org/aos/agrovoc/c_34327 http://aims.fao.org/aos/agrovoc/c_32660 http://aims.fao.org/aos/agrovoc/c_13199 Gain, Clément Rhone, Bénédicte Cubry, Philippe Salazar, Israfel Forbes, Florence Vigouroux, Yves Jay, Flora François, Olivier A quantitative theory for genomic offset statistics |
description |
Genomic offset statistics predict the maladaptation of populations to rapid habitat alteration based on association of genotypes with environmental variation. Despite substantial evidence for empirical validity, genomic offset statistics have well-identified limitations, and lack a theory that would facilitate interpretations of predicted values. Here, we clarified the theoretical relationships between genomic offset statistics and unobserved fitness traits controlled by environmentally selected loci and proposed a geometric measure to predict fitness after rapid change in local environment. The predictions of our theory were verified in computer simulations and in empirical data on African pearl millet (Cenchrus americanus) obtained from a common garden experiment. Our results proposed a unified perspective on genomic offset statistics and provided a theoretical foundation necessary when considering their potential application in conservation management in the face of environmental change. |
format |
article |
topic_facet |
F30 - Génétique et amélioration des plantes U10 - Informatique, mathématiques et statistiques génomique statistiques génétique quantitative analyse quantitative Cenchrus americanus http://aims.fao.org/aos/agrovoc/c_92382 http://aims.fao.org/aos/agrovoc/c_49978 http://aims.fao.org/aos/agrovoc/c_34327 http://aims.fao.org/aos/agrovoc/c_32660 http://aims.fao.org/aos/agrovoc/c_13199 |
author |
Gain, Clément Rhone, Bénédicte Cubry, Philippe Salazar, Israfel Forbes, Florence Vigouroux, Yves Jay, Flora François, Olivier |
author_facet |
Gain, Clément Rhone, Bénédicte Cubry, Philippe Salazar, Israfel Forbes, Florence Vigouroux, Yves Jay, Flora François, Olivier |
author_sort |
Gain, Clément |
title |
A quantitative theory for genomic offset statistics |
title_short |
A quantitative theory for genomic offset statistics |
title_full |
A quantitative theory for genomic offset statistics |
title_fullStr |
A quantitative theory for genomic offset statistics |
title_full_unstemmed |
A quantitative theory for genomic offset statistics |
title_sort |
quantitative theory for genomic offset statistics |
url |
http://agritrop.cirad.fr/605875/ http://agritrop.cirad.fr/605875/1/2023_Gain-etal_MBE_A%20quantitative%20theory%20for%20genomic%20offset%20statistics.pdf |
work_keys_str_mv |
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