A one-health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in France (Ain, Eastern France): A longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation
Tick-borne encephalitis virus' (TBEV) geographic range and the human incidence are increasing throughout Europe, putting a number of non-endemic regions and countries at risk of outbreaks. In spring 2020, there was an outbreak of tick-born encephalitis (TBE) in Ain, Eastern France, where the virus had never been detected before. All patients but one had consumed traditional unpasteurised raw goat cheese from a local producer. We conducted an investigation in the suspected farm using an integrative One Health approach. Our methodology included (i) the detection of virus in cheese and milk products, (ii) serological testing of all animals in the suspected farm and surrounding farms, (iii) an analysis of the landscape and localisation of wooded area, (iv) the capture of questing ticks and small mammals for virus detection and estimating enzootic hazard, and (v) virus isolation and genome sequencing. This approach allowed us to confirm the alimentary origin of the TBE outbreak and witness in real-time the seroconversion of recently exposed individuals and excretion of virus in goat milk. In addition, we identified a wooded focus area where and around which there is a risk of TBEV exposure. We provide the first TBEV isolate responsible for the first alimentary-transmitted TBE in France, obtained its full-length genome sequence, and found that it belongs to the European subtype of TBEV. TBEV is now a notifiable human disease in France, which should facilitate surveillance of its incidence and distribution throughout France.
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | article biblioteca |
Language: | eng |
Subjects: | S50 - Santé humaine, S30 - Régimes alimentaires et maladies nutritionnelles, encéphalite à tiques, maladie transmissible par tiques, maladie de l'homme, fromage de chèvre, lait cru, aliment biologique, Enquête pathologique, surveillance épidémiologique, http://aims.fao.org/aos/agrovoc/c_16818, http://aims.fao.org/aos/agrovoc/c_24908, http://aims.fao.org/aos/agrovoc/c_29198, http://aims.fao.org/aos/agrovoc/c_32463, http://aims.fao.org/aos/agrovoc/c_24225, http://aims.fao.org/aos/agrovoc/c_29261, http://aims.fao.org/aos/agrovoc/c_28665, http://aims.fao.org/aos/agrovoc/c_16411, http://aims.fao.org/aos/agrovoc/c_3081, |
Online Access: | http://agritrop.cirad.fr/601573/ http://agritrop.cirad.fr/601573/1/fmicb-13-863725.pdf |
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S50 - Santé humaine S30 - Régimes alimentaires et maladies nutritionnelles encéphalite à tiques maladie transmissible par tiques maladie de l'homme fromage de chèvre lait cru aliment biologique Enquête pathologique surveillance épidémiologique http://aims.fao.org/aos/agrovoc/c_16818 http://aims.fao.org/aos/agrovoc/c_24908 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_32463 http://aims.fao.org/aos/agrovoc/c_24225 http://aims.fao.org/aos/agrovoc/c_29261 http://aims.fao.org/aos/agrovoc/c_28665 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_3081 S50 - Santé humaine S30 - Régimes alimentaires et maladies nutritionnelles encéphalite à tiques maladie transmissible par tiques maladie de l'homme fromage de chèvre lait cru aliment biologique Enquête pathologique surveillance épidémiologique http://aims.fao.org/aos/agrovoc/c_16818 http://aims.fao.org/aos/agrovoc/c_24908 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_32463 http://aims.fao.org/aos/agrovoc/c_24225 http://aims.fao.org/aos/agrovoc/c_29261 http://aims.fao.org/aos/agrovoc/c_28665 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_3081 |
spellingShingle |
S50 - Santé humaine S30 - Régimes alimentaires et maladies nutritionnelles encéphalite à tiques maladie transmissible par tiques maladie de l'homme fromage de chèvre lait cru aliment biologique Enquête pathologique surveillance épidémiologique http://aims.fao.org/aos/agrovoc/c_16818 http://aims.fao.org/aos/agrovoc/c_24908 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_32463 http://aims.fao.org/aos/agrovoc/c_24225 http://aims.fao.org/aos/agrovoc/c_29261 http://aims.fao.org/aos/agrovoc/c_28665 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_3081 S50 - Santé humaine S30 - Régimes alimentaires et maladies nutritionnelles encéphalite à tiques maladie transmissible par tiques maladie de l'homme fromage de chèvre lait cru aliment biologique Enquête pathologique surveillance épidémiologique http://aims.fao.org/aos/agrovoc/c_16818 http://aims.fao.org/aos/agrovoc/c_24908 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_32463 http://aims.fao.org/aos/agrovoc/c_24225 http://aims.fao.org/aos/agrovoc/c_29261 http://aims.fao.org/aos/agrovoc/c_28665 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_3081 Gonzalez, Gaëlle Bournez, Laure Moares, Rayane Amaral Dumarest, Marine Galon, Clémence Vorimore, Fabien Cochin, Maxime Nougairède, Antoine Hennechart-Collette, Catherine Perelle, Sylvie Leparc-Goffart, Isabelle Durand, Guillaume André Grard, Gilda Bénet, Thomas Danjou, Nathalie Blanchin, Martine Lacour, Sandrine A. Boué, Franck Chenut, Guillaume Mainguet, Catherine Simon, Catherine Brémont, Laurence Zientara, Stéphan Moutailler, Sara Martin-Latil, Sandra Dheilly, Nolwenn M. Beck, Cécile Lecollinet, Sylvie A one-health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in France (Ain, Eastern France): A longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation |
description |
Tick-borne encephalitis virus' (TBEV) geographic range and the human incidence are increasing throughout Europe, putting a number of non-endemic regions and countries at risk of outbreaks. In spring 2020, there was an outbreak of tick-born encephalitis (TBE) in Ain, Eastern France, where the virus had never been detected before. All patients but one had consumed traditional unpasteurised raw goat cheese from a local producer. We conducted an investigation in the suspected farm using an integrative One Health approach. Our methodology included (i) the detection of virus in cheese and milk products, (ii) serological testing of all animals in the suspected farm and surrounding farms, (iii) an analysis of the landscape and localisation of wooded area, (iv) the capture of questing ticks and small mammals for virus detection and estimating enzootic hazard, and (v) virus isolation and genome sequencing. This approach allowed us to confirm the alimentary origin of the TBE outbreak and witness in real-time the seroconversion of recently exposed individuals and excretion of virus in goat milk. In addition, we identified a wooded focus area where and around which there is a risk of TBEV exposure. We provide the first TBEV isolate responsible for the first alimentary-transmitted TBE in France, obtained its full-length genome sequence, and found that it belongs to the European subtype of TBEV. TBEV is now a notifiable human disease in France, which should facilitate surveillance of its incidence and distribution throughout France. |
format |
article |
topic_facet |
S50 - Santé humaine S30 - Régimes alimentaires et maladies nutritionnelles encéphalite à tiques maladie transmissible par tiques maladie de l'homme fromage de chèvre lait cru aliment biologique Enquête pathologique surveillance épidémiologique http://aims.fao.org/aos/agrovoc/c_16818 http://aims.fao.org/aos/agrovoc/c_24908 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_32463 http://aims.fao.org/aos/agrovoc/c_24225 http://aims.fao.org/aos/agrovoc/c_29261 http://aims.fao.org/aos/agrovoc/c_28665 http://aims.fao.org/aos/agrovoc/c_16411 http://aims.fao.org/aos/agrovoc/c_3081 |
author |
Gonzalez, Gaëlle Bournez, Laure Moares, Rayane Amaral Dumarest, Marine Galon, Clémence Vorimore, Fabien Cochin, Maxime Nougairède, Antoine Hennechart-Collette, Catherine Perelle, Sylvie Leparc-Goffart, Isabelle Durand, Guillaume André Grard, Gilda Bénet, Thomas Danjou, Nathalie Blanchin, Martine Lacour, Sandrine A. Boué, Franck Chenut, Guillaume Mainguet, Catherine Simon, Catherine Brémont, Laurence Zientara, Stéphan Moutailler, Sara Martin-Latil, Sandra Dheilly, Nolwenn M. Beck, Cécile Lecollinet, Sylvie |
author_facet |
Gonzalez, Gaëlle Bournez, Laure Moares, Rayane Amaral Dumarest, Marine Galon, Clémence Vorimore, Fabien Cochin, Maxime Nougairède, Antoine Hennechart-Collette, Catherine Perelle, Sylvie Leparc-Goffart, Isabelle Durand, Guillaume André Grard, Gilda Bénet, Thomas Danjou, Nathalie Blanchin, Martine Lacour, Sandrine A. Boué, Franck Chenut, Guillaume Mainguet, Catherine Simon, Catherine Brémont, Laurence Zientara, Stéphan Moutailler, Sara Martin-Latil, Sandra Dheilly, Nolwenn M. Beck, Cécile Lecollinet, Sylvie |
author_sort |
Gonzalez, Gaëlle |
title |
A one-health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in France (Ain, Eastern France): A longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation |
title_short |
A one-health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in France (Ain, Eastern France): A longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation |
title_full |
A one-health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in France (Ain, Eastern France): A longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation |
title_fullStr |
A one-health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in France (Ain, Eastern France): A longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation |
title_full_unstemmed |
A one-health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in France (Ain, Eastern France): A longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation |
title_sort |
one-health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in france (ain, eastern france): a longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation |
url |
http://agritrop.cirad.fr/601573/ http://agritrop.cirad.fr/601573/1/fmicb-13-863725.pdf |
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onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT dumarestmarine onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT galonclemence onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT vorimorefabien onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT cochinmaxime onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT nougairedeantoine onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT hennechartcollettecatherine onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT perellesylvie onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT leparcgoffartisabelle onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT durandguillaumeandre onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT grardgilda onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT benetthomas onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT danjounathalie onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT blanchinmartine onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT lacoursandrinea onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT bouefranck onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT chenutguillaume onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT mainguetcatherine onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT simoncatherine onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT bremontlaurence onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT zientarastephan onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT moutaillersara onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT martinlatilsandra onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT dheillynolwennm onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT beckcecile onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation AT lecollinetsylvie onehealthapproachtoinvestigatinganoutbreakofalimentarytickborneencephalitisinanonendemicareainfranceaineasternfrancealongitudinalserologicalstudyinlivestockdetectioninticksandthefirsttickborneencephalitisvirusisolationandmolecularcharacterisation |
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dig-cirad-fr-6015732024-01-29T19:02:48Z http://agritrop.cirad.fr/601573/ http://agritrop.cirad.fr/601573/ A one-health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in France (Ain, Eastern France): A longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation. Gonzalez Gaëlle, Bournez Laure, Moares Rayane Amaral, Dumarest Marine, Galon Clémence, Vorimore Fabien, Cochin Maxime, Nougairède Antoine, Hennechart-Collette Catherine, Perelle Sylvie, Leparc-Goffart Isabelle, Durand Guillaume André, Grard Gilda, Bénet Thomas, Danjou Nathalie, Blanchin Martine, Lacour Sandrine A., Boué Franck, Chenut Guillaume, Mainguet Catherine, Simon Catherine, Brémont Laurence, Zientara Stéphan, Moutailler Sara, Martin-Latil Sandra, Dheilly Nolwenn M., Beck Cécile, Lecollinet Sylvie. 2022. Frontiers in Microbiology, 13:863725, 15 p.https://doi.org/10.3389/fmicb.2022.863725 <https://doi.org/10.3389/fmicb.2022.863725> A one-health approach to investigating an outbreak of alimentary tick-borne encephalitis in a non-endemic area in France (Ain, Eastern France): A longitudinal serological study in livestock, detection in ticks, and the first tick-borne encephalitis virus isolation and molecular characterisation Gonzalez, Gaëlle Bournez, Laure Moares, Rayane Amaral Dumarest, Marine Galon, Clémence Vorimore, Fabien Cochin, Maxime Nougairède, Antoine Hennechart-Collette, Catherine Perelle, Sylvie Leparc-Goffart, Isabelle Durand, Guillaume André Grard, Gilda Bénet, Thomas Danjou, Nathalie Blanchin, Martine Lacour, Sandrine A. Boué, Franck Chenut, Guillaume Mainguet, Catherine Simon, Catherine Brémont, Laurence Zientara, Stéphan Moutailler, Sara Martin-Latil, Sandra Dheilly, Nolwenn M. Beck, Cécile Lecollinet, Sylvie eng 2022 Frontiers in Microbiology S50 - Santé humaine S30 - Régimes alimentaires et maladies nutritionnelles encéphalite à tiques maladie transmissible par tiques maladie de l'homme fromage de chèvre lait cru aliment biologique Enquête pathologique surveillance épidémiologique http://aims.fao.org/aos/agrovoc/c_16818 http://aims.fao.org/aos/agrovoc/c_24908 http://aims.fao.org/aos/agrovoc/c_29198 http://aims.fao.org/aos/agrovoc/c_32463 http://aims.fao.org/aos/agrovoc/c_24225 http://aims.fao.org/aos/agrovoc/c_29261 http://aims.fao.org/aos/agrovoc/c_28665 http://aims.fao.org/aos/agrovoc/c_16411 France http://aims.fao.org/aos/agrovoc/c_3081 Tick-borne encephalitis virus' (TBEV) geographic range and the human incidence are increasing throughout Europe, putting a number of non-endemic regions and countries at risk of outbreaks. In spring 2020, there was an outbreak of tick-born encephalitis (TBE) in Ain, Eastern France, where the virus had never been detected before. All patients but one had consumed traditional unpasteurised raw goat cheese from a local producer. We conducted an investigation in the suspected farm using an integrative One Health approach. Our methodology included (i) the detection of virus in cheese and milk products, (ii) serological testing of all animals in the suspected farm and surrounding farms, (iii) an analysis of the landscape and localisation of wooded area, (iv) the capture of questing ticks and small mammals for virus detection and estimating enzootic hazard, and (v) virus isolation and genome sequencing. This approach allowed us to confirm the alimentary origin of the TBE outbreak and witness in real-time the seroconversion of recently exposed individuals and excretion of virus in goat milk. In addition, we identified a wooded focus area where and around which there is a risk of TBEV exposure. We provide the first TBEV isolate responsible for the first alimentary-transmitted TBE in France, obtained its full-length genome sequence, and found that it belongs to the European subtype of TBEV. TBEV is now a notifiable human disease in France, which should facilitate surveillance of its incidence and distribution throughout France. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/601573/1/fmicb-13-863725.pdf text cc_by info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0/ https://doi.org/10.3389/fmicb.2022.863725 10.3389/fmicb.2022.863725 info:eu-repo/semantics/altIdentifier/doi/10.3389/fmicb.2022.863725 info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.3389/fmicb.2022.863725 info:eu-repo/semantics/dataset/purl/https://figshare.com/collections/A_One-Health_Approach_to_Investigating_an_Outbreak_of_Alimentary_Tick-Borne_Encephalitis_in_a_Non-endemic_Area_in_France_Ain_Eastern_France_A_Longitudinal_Serological_Study_in_Livestock_Detection_in_Ticks_and_the_First_Tic |