Preventive action of retinoids in metabolic syndrome/type 2 diabetic rats fed with citrus functional food enriched in β-cryptoxanthin
Citrus fruits are known for their beneficial health effects associated with the prevention of metabolic syndrome/type 2 diabetes that is mainly attributed to flavonoids. Few investigations have reported the potential anti-diabetic effects of retinoids from the bioconversion of β-cryptoxanthin (bcx), a citrus carotenoid. Therefore, the present study explored the anti-diabetic effect of a citrus functional food, obtained by membrane eco-technology of a citrus clementina juice, especially enriched in bcx but also in flavonoids and pectin. We assessed the in vivo effect of citrus bcx absorption and its bioconversion into retinoids in metabolic syndrome/type 2 diabetic fructose rats. Fructose-fed rats were used as a prediabetic control, and a prediabetic group was treated with the citrus concentrate for 8 weeks. The citrus-based food treatment improved glucose tolerance, dyslipidemia and blood pressure, in prediabetic rats. Although these effects were in part due to the synergy between enriched phytonutrients (bcx, hesperidin, pectin) of the citrus matrix, the role of bcx and its bioconversion into retinoids were highlighted. We showed that prediabetic rats absorbed less bcx and the bioconversion was less efficient. Bcx from citrus-based food was able to restore vitamin A status in prediabetic rats suggesting that the absorption/bioconversion of bcx may have a key role in improvement of metabolic syndrome/type 2 diabetes.
Main Authors: | , , , , |
---|---|
Format: | article biblioteca |
Language: | eng |
Subjects: | S50 - Santé humaine, Q04 - Composition des produits alimentaires, prévention des maladies, aliment santé pour homme, diabète, flavonoïde, agrume, caroténoïde, jus de fruits, http://aims.fao.org/aos/agrovoc/c_10394, http://aims.fao.org/aos/agrovoc/c_25396, http://aims.fao.org/aos/agrovoc/c_10361, http://aims.fao.org/aos/agrovoc/c_2964, http://aims.fao.org/aos/agrovoc/c_1641, http://aims.fao.org/aos/agrovoc/c_1333, http://aims.fao.org/aos/agrovoc/c_3123, |
Online Access: | http://agritrop.cirad.fr/599912/ http://agritrop.cirad.fr/599912/1/599912.pdf |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
dig-cirad-fr-599912 |
---|---|
record_format |
koha |
spelling |
dig-cirad-fr-5999122024-01-29T03:56:25Z http://agritrop.cirad.fr/599912/ http://agritrop.cirad.fr/599912/ Preventive action of retinoids in metabolic syndrome/type 2 diabetic rats fed with citrus functional food enriched in β-cryptoxanthin. Dhuique-Mayer Claudie, Gence Laura, Portet Karine, Tousch Didier, Poucheret Patrick. 2020. Food and Function, 11 (10) : 9263-9271.https://doi.org/10.1039/d0fo02430a <https://doi.org/10.1039/d0fo02430a> Preventive action of retinoids in metabolic syndrome/type 2 diabetic rats fed with citrus functional food enriched in β-cryptoxanthin Dhuique-Mayer, Claudie Gence, Laura Portet, Karine Tousch, Didier Poucheret, Patrick eng 2020 Food and Function S50 - Santé humaine Q04 - Composition des produits alimentaires prévention des maladies aliment santé pour homme diabète flavonoïde agrume caroténoïde jus de fruits http://aims.fao.org/aos/agrovoc/c_10394 http://aims.fao.org/aos/agrovoc/c_25396 http://aims.fao.org/aos/agrovoc/c_10361 http://aims.fao.org/aos/agrovoc/c_2964 http://aims.fao.org/aos/agrovoc/c_1641 http://aims.fao.org/aos/agrovoc/c_1333 http://aims.fao.org/aos/agrovoc/c_3123 Citrus fruits are known for their beneficial health effects associated with the prevention of metabolic syndrome/type 2 diabetes that is mainly attributed to flavonoids. Few investigations have reported the potential anti-diabetic effects of retinoids from the bioconversion of β-cryptoxanthin (bcx), a citrus carotenoid. Therefore, the present study explored the anti-diabetic effect of a citrus functional food, obtained by membrane eco-technology of a citrus clementina juice, especially enriched in bcx but also in flavonoids and pectin. We assessed the in vivo effect of citrus bcx absorption and its bioconversion into retinoids in metabolic syndrome/type 2 diabetic fructose rats. Fructose-fed rats were used as a prediabetic control, and a prediabetic group was treated with the citrus concentrate for 8 weeks. The citrus-based food treatment improved glucose tolerance, dyslipidemia and blood pressure, in prediabetic rats. Although these effects were in part due to the synergy between enriched phytonutrients (bcx, hesperidin, pectin) of the citrus matrix, the role of bcx and its bioconversion into retinoids were highlighted. We showed that prediabetic rats absorbed less bcx and the bioconversion was less efficient. Bcx from citrus-based food was able to restore vitamin A status in prediabetic rats suggesting that the absorption/bioconversion of bcx may have a key role in improvement of metabolic syndrome/type 2 diabetes. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/599912/1/599912.pdf text Cirad license info:eu-repo/semantics/restrictedAccess https://agritrop.cirad.fr/mention_legale.html https://doi.org/10.1039/d0fo02430a 10.1039/d0fo02430a info:eu-repo/semantics/altIdentifier/doi/10.1039/d0fo02430a info:eu-repo/semantics/altIdentifier/purl/https://doi.org/10.1039/d0fo02430a |
institution |
CIRAD FR |
collection |
DSpace |
country |
Francia |
countrycode |
FR |
component |
Bibliográfico |
access |
En linea |
databasecode |
dig-cirad-fr |
tag |
biblioteca |
region |
Europa del Oeste |
libraryname |
Biblioteca del CIRAD Francia |
language |
eng |
topic |
S50 - Santé humaine Q04 - Composition des produits alimentaires prévention des maladies aliment santé pour homme diabète flavonoïde agrume caroténoïde jus de fruits http://aims.fao.org/aos/agrovoc/c_10394 http://aims.fao.org/aos/agrovoc/c_25396 http://aims.fao.org/aos/agrovoc/c_10361 http://aims.fao.org/aos/agrovoc/c_2964 http://aims.fao.org/aos/agrovoc/c_1641 http://aims.fao.org/aos/agrovoc/c_1333 http://aims.fao.org/aos/agrovoc/c_3123 S50 - Santé humaine Q04 - Composition des produits alimentaires prévention des maladies aliment santé pour homme diabète flavonoïde agrume caroténoïde jus de fruits http://aims.fao.org/aos/agrovoc/c_10394 http://aims.fao.org/aos/agrovoc/c_25396 http://aims.fao.org/aos/agrovoc/c_10361 http://aims.fao.org/aos/agrovoc/c_2964 http://aims.fao.org/aos/agrovoc/c_1641 http://aims.fao.org/aos/agrovoc/c_1333 http://aims.fao.org/aos/agrovoc/c_3123 |
spellingShingle |
S50 - Santé humaine Q04 - Composition des produits alimentaires prévention des maladies aliment santé pour homme diabète flavonoïde agrume caroténoïde jus de fruits http://aims.fao.org/aos/agrovoc/c_10394 http://aims.fao.org/aos/agrovoc/c_25396 http://aims.fao.org/aos/agrovoc/c_10361 http://aims.fao.org/aos/agrovoc/c_2964 http://aims.fao.org/aos/agrovoc/c_1641 http://aims.fao.org/aos/agrovoc/c_1333 http://aims.fao.org/aos/agrovoc/c_3123 S50 - Santé humaine Q04 - Composition des produits alimentaires prévention des maladies aliment santé pour homme diabète flavonoïde agrume caroténoïde jus de fruits http://aims.fao.org/aos/agrovoc/c_10394 http://aims.fao.org/aos/agrovoc/c_25396 http://aims.fao.org/aos/agrovoc/c_10361 http://aims.fao.org/aos/agrovoc/c_2964 http://aims.fao.org/aos/agrovoc/c_1641 http://aims.fao.org/aos/agrovoc/c_1333 http://aims.fao.org/aos/agrovoc/c_3123 Dhuique-Mayer, Claudie Gence, Laura Portet, Karine Tousch, Didier Poucheret, Patrick Preventive action of retinoids in metabolic syndrome/type 2 diabetic rats fed with citrus functional food enriched in β-cryptoxanthin |
description |
Citrus fruits are known for their beneficial health effects associated with the prevention of metabolic syndrome/type 2 diabetes that is mainly attributed to flavonoids. Few investigations have reported the potential anti-diabetic effects of retinoids from the bioconversion of β-cryptoxanthin (bcx), a citrus carotenoid. Therefore, the present study explored the anti-diabetic effect of a citrus functional food, obtained by membrane eco-technology of a citrus clementina juice, especially enriched in bcx but also in flavonoids and pectin. We assessed the in vivo effect of citrus bcx absorption and its bioconversion into retinoids in metabolic syndrome/type 2 diabetic fructose rats. Fructose-fed rats were used as a prediabetic control, and a prediabetic group was treated with the citrus concentrate for 8 weeks. The citrus-based food treatment improved glucose tolerance, dyslipidemia and blood pressure, in prediabetic rats. Although these effects were in part due to the synergy between enriched phytonutrients (bcx, hesperidin, pectin) of the citrus matrix, the role of bcx and its bioconversion into retinoids were highlighted. We showed that prediabetic rats absorbed less bcx and the bioconversion was less efficient. Bcx from citrus-based food was able to restore vitamin A status in prediabetic rats suggesting that the absorption/bioconversion of bcx may have a key role in improvement of metabolic syndrome/type 2 diabetes. |
format |
article |
topic_facet |
S50 - Santé humaine Q04 - Composition des produits alimentaires prévention des maladies aliment santé pour homme diabète flavonoïde agrume caroténoïde jus de fruits http://aims.fao.org/aos/agrovoc/c_10394 http://aims.fao.org/aos/agrovoc/c_25396 http://aims.fao.org/aos/agrovoc/c_10361 http://aims.fao.org/aos/agrovoc/c_2964 http://aims.fao.org/aos/agrovoc/c_1641 http://aims.fao.org/aos/agrovoc/c_1333 http://aims.fao.org/aos/agrovoc/c_3123 |
author |
Dhuique-Mayer, Claudie Gence, Laura Portet, Karine Tousch, Didier Poucheret, Patrick |
author_facet |
Dhuique-Mayer, Claudie Gence, Laura Portet, Karine Tousch, Didier Poucheret, Patrick |
author_sort |
Dhuique-Mayer, Claudie |
title |
Preventive action of retinoids in metabolic syndrome/type 2 diabetic rats fed with citrus functional food enriched in β-cryptoxanthin |
title_short |
Preventive action of retinoids in metabolic syndrome/type 2 diabetic rats fed with citrus functional food enriched in β-cryptoxanthin |
title_full |
Preventive action of retinoids in metabolic syndrome/type 2 diabetic rats fed with citrus functional food enriched in β-cryptoxanthin |
title_fullStr |
Preventive action of retinoids in metabolic syndrome/type 2 diabetic rats fed with citrus functional food enriched in β-cryptoxanthin |
title_full_unstemmed |
Preventive action of retinoids in metabolic syndrome/type 2 diabetic rats fed with citrus functional food enriched in β-cryptoxanthin |
title_sort |
preventive action of retinoids in metabolic syndrome/type 2 diabetic rats fed with citrus functional food enriched in β-cryptoxanthin |
url |
http://agritrop.cirad.fr/599912/ http://agritrop.cirad.fr/599912/1/599912.pdf |
work_keys_str_mv |
AT dhuiquemayerclaudie preventiveactionofretinoidsinmetabolicsyndrometype2diabeticratsfedwithcitrusfunctionalfoodenrichedinbcryptoxanthin AT gencelaura preventiveactionofretinoidsinmetabolicsyndrometype2diabeticratsfedwithcitrusfunctionalfoodenrichedinbcryptoxanthin AT portetkarine preventiveactionofretinoidsinmetabolicsyndrometype2diabeticratsfedwithcitrusfunctionalfoodenrichedinbcryptoxanthin AT touschdidier preventiveactionofretinoidsinmetabolicsyndrometype2diabeticratsfedwithcitrusfunctionalfoodenrichedinbcryptoxanthin AT poucheretpatrick preventiveactionofretinoidsinmetabolicsyndrometype2diabeticratsfedwithcitrusfunctionalfoodenrichedinbcryptoxanthin |
_version_ |
1792500277654323200 |