Characterization of anamnestic T-cell responses induced by conventional vaccines against contagious bovine pleuropneumonia
A better understanding of how T1 vaccination confers immunity would facilitate the rational design of improved vaccines against contagious bovine pleuropneumonia (CBPP). We show here that mycoplasmas-induced recall proliferation and IFN-c responses are detected in cattle that received multiple shots of T1 vaccines. These anamnestic responses were under the strict control of CD4+ T lymphocytes. Moreover, CD62L expression indicated that both CD4+ effector memory (Tem) and central memory (Tcm) T lymphocytes are elicited in these animals. Comparative analysis with data from cattle that completely recovered from CBPP infection revealed similar anamnestic T-cell responses albeit at a lower magnitude for T1- vaccinated animals, particularly in the Tcm compartment. In conclusion, we discuss how our current understanding of T-cell responses will contribute to ongoing efforts for the improvement of future CBPP vaccines.
| Main Authors: | , , , , , , , |
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| Format: | article biblioteca |
| Language: | eng |
| Subjects: | L73 - Maladies des animaux, L50 - Physiologie et biochimie animales, péripneumonie contagieuse bovine, Mycoplasma mycoides, bovin, vaccin, immunologie, lymphocyte, réponse immunitaire, vaccination, http://aims.fao.org/aos/agrovoc/c_16706, http://aims.fao.org/aos/agrovoc/c_23951, http://aims.fao.org/aos/agrovoc/c_1391, http://aims.fao.org/aos/agrovoc/c_8130, http://aims.fao.org/aos/agrovoc/c_3808, http://aims.fao.org/aos/agrovoc/c_4484, http://aims.fao.org/aos/agrovoc/c_3799, http://aims.fao.org/aos/agrovoc/c_15123, http://aims.fao.org/aos/agrovoc/c_1229, http://aims.fao.org/aos/agrovoc/c_4086, http://aims.fao.org/aos/agrovoc/c_4540, |
| Online Access: | http://agritrop.cirad.fr/568452/ http://agritrop.cirad.fr/568452/1/document_568452.pdf |
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