Experimental studies on the effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia-infected cattle
The effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia (CBPP)-infected animals was determined. Thirty five clinically healthy zebu cattle, negative for CBPP antibodies (as tested by a competitive ELISA), were infected with Mycoplasma mycoides subsp. mycoides small colony variant - field isolate. All the animals were monitored for clinical signs of illness and regularly sampled for serological and bacteriological analysis. Nine animals were treated with long-acting tetracycline upon the first evidence of clinical signs of illness. The 26 remaining animals were left untreated and served as control animals. Post-mortem examinations were performed to assess the presence or absence of CBPP gross lesions. The experimentation lasted for 10 months during which, 13 animals (all untreated) died with acute lung lesions. When the 22 surviving animals (13 untreated and 9 treated) were slaughtered at the end of experimentation, chronic lesions were observed in all of them. Among the 13 untreated animals, 10 had visible lung sequestra and 3 had cicatrical lesions indicative of resolved lung lesions. Conversely, among the 9 treated animals, only 1 had a small lung sequestrum and the remaining 8 had pulmonary adhesions. The results presented demonstrate that, under the experimental conditions used, treatment with oxytetracycline did not result in significant sequestra formation in CBPP-infected animals. Full field validation is required in order to confirm these findings.
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Subjects: | L73 - Maladies des animaux, péripneumonie contagieuse bovine, Mycoplasma mycoides, zébu, oxytétracycline, http://aims.fao.org/aos/agrovoc/c_16706, http://aims.fao.org/aos/agrovoc/c_23951, http://aims.fao.org/aos/agrovoc/c_8507, http://aims.fao.org/aos/agrovoc/c_13011, http://aims.fao.org/aos/agrovoc/c_4540, |
Online Access: | http://agritrop.cirad.fr/558021/ http://agritrop.cirad.fr/558021/1/document_558021.pdf |
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dig-cirad-fr-5580212024-01-28T18:50:58Z http://agritrop.cirad.fr/558021/ http://agritrop.cirad.fr/558021/ Experimental studies on the effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia-infected cattle. Niang Mamadou, Sery Amadou, Doucoure Modibo, Kone Mamadou, N'Diaye M., Amanfu William, Thiaucourt François. 2010. Journal of Veterinary Medicine and Animal Health, 2 (4) : 35-45. Experimental studies on the effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia-infected cattle Niang, Mamadou Sery, Amadou Doucoure, Modibo Kone, Mamadou N'Diaye, M. Amanfu, William Thiaucourt, François eng 2010 Journal of Veterinary Medicine and Animal Health L73 - Maladies des animaux péripneumonie contagieuse bovine Mycoplasma mycoides zébu oxytétracycline http://aims.fao.org/aos/agrovoc/c_16706 http://aims.fao.org/aos/agrovoc/c_23951 http://aims.fao.org/aos/agrovoc/c_8507 http://aims.fao.org/aos/agrovoc/c_13011 Mali http://aims.fao.org/aos/agrovoc/c_4540 The effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia (CBPP)-infected animals was determined. Thirty five clinically healthy zebu cattle, negative for CBPP antibodies (as tested by a competitive ELISA), were infected with Mycoplasma mycoides subsp. mycoides small colony variant - field isolate. All the animals were monitored for clinical signs of illness and regularly sampled for serological and bacteriological analysis. Nine animals were treated with long-acting tetracycline upon the first evidence of clinical signs of illness. The 26 remaining animals were left untreated and served as control animals. Post-mortem examinations were performed to assess the presence or absence of CBPP gross lesions. The experimentation lasted for 10 months during which, 13 animals (all untreated) died with acute lung lesions. When the 22 surviving animals (13 untreated and 9 treated) were slaughtered at the end of experimentation, chronic lesions were observed in all of them. Among the 13 untreated animals, 10 had visible lung sequestra and 3 had cicatrical lesions indicative of resolved lung lesions. Conversely, among the 9 treated animals, only 1 had a small lung sequestrum and the remaining 8 had pulmonary adhesions. The results presented demonstrate that, under the experimental conditions used, treatment with oxytetracycline did not result in significant sequestra formation in CBPP-infected animals. Full field validation is required in order to confirm these findings. article info:eu-repo/semantics/article Journal Article info:eu-repo/semantics/publishedVersion http://agritrop.cirad.fr/558021/1/document_558021.pdf application/pdf Cirad license info:eu-repo/semantics/openAccess https://agritrop.cirad.fr/mention_legale.html http://catalogue-bibliotheques.cirad.fr/cgi-bin/koha/opac-detail.pl?biblionumber=190998 |
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L73 - Maladies des animaux péripneumonie contagieuse bovine Mycoplasma mycoides zébu oxytétracycline http://aims.fao.org/aos/agrovoc/c_16706 http://aims.fao.org/aos/agrovoc/c_23951 http://aims.fao.org/aos/agrovoc/c_8507 http://aims.fao.org/aos/agrovoc/c_13011 http://aims.fao.org/aos/agrovoc/c_4540 L73 - Maladies des animaux péripneumonie contagieuse bovine Mycoplasma mycoides zébu oxytétracycline http://aims.fao.org/aos/agrovoc/c_16706 http://aims.fao.org/aos/agrovoc/c_23951 http://aims.fao.org/aos/agrovoc/c_8507 http://aims.fao.org/aos/agrovoc/c_13011 http://aims.fao.org/aos/agrovoc/c_4540 |
spellingShingle |
L73 - Maladies des animaux péripneumonie contagieuse bovine Mycoplasma mycoides zébu oxytétracycline http://aims.fao.org/aos/agrovoc/c_16706 http://aims.fao.org/aos/agrovoc/c_23951 http://aims.fao.org/aos/agrovoc/c_8507 http://aims.fao.org/aos/agrovoc/c_13011 http://aims.fao.org/aos/agrovoc/c_4540 L73 - Maladies des animaux péripneumonie contagieuse bovine Mycoplasma mycoides zébu oxytétracycline http://aims.fao.org/aos/agrovoc/c_16706 http://aims.fao.org/aos/agrovoc/c_23951 http://aims.fao.org/aos/agrovoc/c_8507 http://aims.fao.org/aos/agrovoc/c_13011 http://aims.fao.org/aos/agrovoc/c_4540 Niang, Mamadou Sery, Amadou Doucoure, Modibo Kone, Mamadou N'Diaye, M. Amanfu, William Thiaucourt, François Experimental studies on the effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia-infected cattle |
description |
The effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia (CBPP)-infected animals was determined. Thirty five clinically healthy zebu cattle, negative for CBPP antibodies (as tested by a competitive ELISA), were infected with Mycoplasma mycoides subsp. mycoides small colony variant - field isolate. All the animals were monitored for clinical signs of illness and regularly sampled for serological and bacteriological analysis. Nine animals were treated with long-acting tetracycline upon the first evidence of clinical signs of illness. The 26 remaining animals were left untreated and served as control animals. Post-mortem examinations were performed to assess the presence or absence of CBPP gross lesions. The experimentation lasted for 10 months during which, 13 animals (all untreated) died with acute lung lesions. When the 22 surviving animals (13 untreated and 9 treated) were slaughtered at the end of experimentation, chronic lesions were observed in all of them. Among the 13 untreated animals, 10 had visible lung sequestra and 3 had cicatrical lesions indicative of resolved lung lesions. Conversely, among the 9 treated animals, only 1 had a small lung sequestrum and the remaining 8 had pulmonary adhesions. The results presented demonstrate that, under the experimental conditions used, treatment with oxytetracycline did not result in significant sequestra formation in CBPP-infected animals. Full field validation is required in order to confirm these findings. |
format |
article |
topic_facet |
L73 - Maladies des animaux péripneumonie contagieuse bovine Mycoplasma mycoides zébu oxytétracycline http://aims.fao.org/aos/agrovoc/c_16706 http://aims.fao.org/aos/agrovoc/c_23951 http://aims.fao.org/aos/agrovoc/c_8507 http://aims.fao.org/aos/agrovoc/c_13011 http://aims.fao.org/aos/agrovoc/c_4540 |
author |
Niang, Mamadou Sery, Amadou Doucoure, Modibo Kone, Mamadou N'Diaye, M. Amanfu, William Thiaucourt, François |
author_facet |
Niang, Mamadou Sery, Amadou Doucoure, Modibo Kone, Mamadou N'Diaye, M. Amanfu, William Thiaucourt, François |
author_sort |
Niang, Mamadou |
title |
Experimental studies on the effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia-infected cattle |
title_short |
Experimental studies on the effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia-infected cattle |
title_full |
Experimental studies on the effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia-infected cattle |
title_fullStr |
Experimental studies on the effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia-infected cattle |
title_full_unstemmed |
Experimental studies on the effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia-infected cattle |
title_sort |
experimental studies on the effect of long-acting oxytetracycline treatment in the development of sequestra in contagious bovine pleuropneumonia-infected cattle |
url |
http://agritrop.cirad.fr/558021/ http://agritrop.cirad.fr/558021/1/document_558021.pdf |
work_keys_str_mv |
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