Application of novel genotyping microarray technologies in cancer research
Cancer is a genetic disease. The impact of genetic alterations of tumor cells on cancer patient prognosis and treatment has been extensively demonstrated in the past decades. In addition, based on the knowledge of the essential role of genetic alterations in tumor development and progression, a new generation of targeted antitumoral drugs is being developed with outstanding results, providing evidence of the necessity of stratification of cancer patients according to their genetic characteristics. Scientific discoveries resulting from the application of DNA sequencing technologies have supported the continuous development of genotyping technologies, highlighting its impact both to enhance basic biological knowledge and to provide new tools for patient stratification. This chapter will review some of the most common techniques used to analyze human genetic variation, together with the most relevant discoveries in cancer research leading to the introduction of cancer genetics to the clinical setting. © 2014 Elsevier B.V.
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Format: | capítulo de libro biblioteca |
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Elsevier
2014
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Subjects: | Targeted therapy, Sequencing technologies, Genetic variation, Cancer, |
Online Access: | http://hdl.handle.net/10261/99781 |
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dig-cial-es-10261-997812018-09-18T10:31:01Z Application of novel genotyping microarray technologies in cancer research Ramos, Ricardo Moreno-Rubio, Juan Casado, Enrique Reglero, Guillermo Ramírez de Molina, Ana Targeted therapy Sequencing technologies Genetic variation Cancer Cancer is a genetic disease. The impact of genetic alterations of tumor cells on cancer patient prognosis and treatment has been extensively demonstrated in the past decades. In addition, based on the knowledge of the essential role of genetic alterations in tumor development and progression, a new generation of targeted antitumoral drugs is being developed with outstanding results, providing evidence of the necessity of stratification of cancer patients according to their genetic characteristics. Scientific discoveries resulting from the application of DNA sequencing technologies have supported the continuous development of genotyping technologies, highlighting its impact both to enhance basic biological knowledge and to provide new tools for patient stratification. This chapter will review some of the most common techniques used to analyze human genetic variation, together with the most relevant discoveries in cancer research leading to the introduction of cancer genetics to the clinical setting. © 2014 Elsevier B.V. Peer Reviewed 2014-07-14T10:05:16Z 2014-07-14T10:05:16Z 2014 2014-07-14T10:05:16Z capítulo de libro http://purl.org/coar/resource_type/c_3248 doi: 10.1016/B978-0-444-62650-9.00003-8 isbn: 978-0-444-62650-9 Applications of Advanced Omics Technologies: From Genes to Metabolites (Cap.3): 47-73 (2014) http://hdl.handle.net/10261/99781 10.1016/B978-0-444-62650-9.00003-8 Comprehensive Analytical Chemistry 64 Sí none Elsevier |
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Targeted therapy Sequencing technologies Genetic variation Cancer Targeted therapy Sequencing technologies Genetic variation Cancer Ramos, Ricardo Moreno-Rubio, Juan Casado, Enrique Reglero, Guillermo Ramírez de Molina, Ana Application of novel genotyping microarray technologies in cancer research |
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Cancer is a genetic disease. The impact of genetic alterations of tumor cells on cancer patient prognosis and treatment has been extensively demonstrated in the past decades. In addition, based on the knowledge of the essential role of genetic alterations in tumor development and progression, a new generation of targeted antitumoral drugs is being developed with outstanding results, providing evidence of the necessity of stratification of cancer patients according to their genetic characteristics. Scientific discoveries resulting from the application of DNA sequencing technologies have supported the continuous development of genotyping technologies, highlighting its impact both to enhance basic biological knowledge and to provide new tools for patient stratification. This chapter will review some of the most common techniques used to analyze human genetic variation, together with the most relevant discoveries in cancer research leading to the introduction of cancer genetics to the clinical setting. © 2014 Elsevier B.V. |
format |
capítulo de libro |
topic_facet |
Targeted therapy Sequencing technologies Genetic variation Cancer |
author |
Ramos, Ricardo Moreno-Rubio, Juan Casado, Enrique Reglero, Guillermo Ramírez de Molina, Ana |
author_facet |
Ramos, Ricardo Moreno-Rubio, Juan Casado, Enrique Reglero, Guillermo Ramírez de Molina, Ana |
author_sort |
Ramos, Ricardo |
title |
Application of novel genotyping microarray technologies in cancer research |
title_short |
Application of novel genotyping microarray technologies in cancer research |
title_full |
Application of novel genotyping microarray technologies in cancer research |
title_fullStr |
Application of novel genotyping microarray technologies in cancer research |
title_full_unstemmed |
Application of novel genotyping microarray technologies in cancer research |
title_sort |
application of novel genotyping microarray technologies in cancer research |
publisher |
Elsevier |
publishDate |
2014 |
url |
http://hdl.handle.net/10261/99781 |
work_keys_str_mv |
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1777671132216819712 |