Hass avocado (Persea americana Mill.) residues as a new potential source of neuroprotective compounds using pressurized liquid extraction

Epicarp and seed of Hass avocado (Persea americana Mill.) are agro-industrial residues rich in bioactive compounds. In this study, a pressurized liquid extraction (PLE) method was optimized to obtain phenolic compound-rich extracts with neuroprotective potential. The optimal extracts, obtained from 100% epicarp with pure water (0% ethanol) at 40 °C and 100 bar, demonstrated high extraction yield (26.8 ± 0.9%) and total phenol content (TPC = 505 ± 25 mg gallic acid equivalent/g dry extract), good antioxidant capacity (ABTS = 3350 ± 179 µmol Trolox equivalent/g dry extract, ORAC = 0.14 ± 0.01 µg/mL), and moderate acetylcholinesterase inhibition (33.6 ± 2.9 µg/mL). UHPLC-ESI-QTOF-MS analysis of the optimal extracts tentatively identified phenolic acids, phenolic alcohol derivatives, and various flavonoids; namely flavonols. The results reveal the potential of avocado processing by-products, particularly the epicarp, as source of potential neuroprotective agents. The proposed PLE methodology was demonstrated to be a sustainable and efficient strategy for avocado residues valorization.

Bibliographic Details

Main Authors:	Grisales-Mejía, Juan Felipe, Álvarez-Rivera, Gerardo, Torres-Castañeda, Harlen G., Andrade-Mahecha, Margarita M., Martínez-Correa, Hugo A., Mendiola, J. A., Cifuentes, Alejandro, Ibáñez, Elena
Other Authors:	Ministerio de Ciencia e Innovación (España)
Format:	artículo biblioteca
Language:	English
Published:	Elsevier 2024
Subjects:	Pressurized liquid extraction, Neuroprotective activity, Avocado by-products, Green extraction, Polyphenols, LC-QTOF-MS,
Online Access:	http://hdl.handle.net/10261/358870
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