Multifunctionality and bioavailability of peptides derived from Erythrina edulis (pajuro) protein

Intiquilla, Arturo; Indiano-Romacho, Pedro; Jiménez-Aliaga, Karim; Izaguirre, Víctor; Zavaleta, Amparo I.; Amigo, Lourdes; Hernández-Ledesma, Blanca; Ministerio de Economía y Competitividad (España)

Multifunctionality and bioavailability of peptides derived from Erythrina edulis (pajuro) protein

Trabajo presentado a la 2nd International Conference on Food Bioactives and Health, celebrada en Lisboa (Portugal) del 26 al 28 de septiembre de 2018.

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Bibliographic Details
Main Authors:	Intiquilla, Arturo, Indiano-Romacho, Pedro, Jiménez-Aliaga, Karim, Izaguirre, Víctor, Zavaleta, Amparo I., Amigo, Lourdes, Hernández-Ledesma, Blanca
Other Authors:	Ministerio de Economía y Competitividad (España)
Format:	póster de congreso biblioteca
Language:	English
Published:	2018
Subjects:	Erythrina edulis, Multifunctional peptides, Bioavailability,
Online Access:	http://hdl.handle.net/10261/194798 http://dx.doi.org/10.13039/501100003329
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spelling	dig-cial-es-10261-1947982019-11-19T02:03:10Z Multifunctionality and bioavailability of peptides derived from Erythrina edulis (pajuro) protein Intiquilla, Arturo Indiano-Romacho, Pedro Jiménez-Aliaga, Karim Izaguirre, Víctor Zavaleta, Amparo I. Amigo, Lourdes Hernández-Ledesma, Blanca Ministerio de Economía y Competitividad (España) Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo Erythrina edulis Multifunctional peptides Bioavailability Trabajo presentado a la 2nd International Conference on Food Bioactives and Health, celebrada en Lisboa (Portugal) del 26 al 28 de septiembre de 2018. Cardiovascular disease and type 2 diabetes are majar causes of death in developed countries. These diseases are associated with each other and linked with oxidative stress. Currently, the research interest has focused on the characterization of food-derived multifunctional peptides with preventive and/or therapeutic potential against chronic disorders. One of the greatest challenges in using bioactive peptides for the modulation of physiological functions is their bioavailability. Survival of gastrointestinal digestion and intestinal epithelial absorption in the human digestive tract are essential prerequisites for bioactive peptides to have any impact. Erythrina edulis (pajuro) is a legume with a broad range of uses because of its nutritional and health promoting properties. This plant contains an elevated content of protein with high quality and digestibility, and potential to release bioactive peptides. The antioxidant properties of pajuro protein hydrolyzates with alcalase have been recently reported. The objective of this research was to identify the peptides contained in those hydrolyzates, and evaluate their multifunctionality and bioavailability. Among 29 peptides identified by MALDI-TOF and HPLC-ESI-MS/MS, 17 were selected according to their structure and synthesized. The antioxidant, anti-inflammatory and dipeptidyl peptidase IV (DPPIV) inhibitory activities were evaluated. Most active fragments were subjected to simulated gastrointestinal digestion and their bioavailability was studied in the Caco-2 cell model. The results confirm the role of pajuro proteins as source of multifunctional and bioavailable peptides with potential as novel ingredients of functional foods to prevent and/or manage diabetes and oxidative-stress related disorders. This work has received financial support from projects 186-FINCyT-IA-2013 (Programa Nacional de Innovación para la Competitividad y Productividad (Innovate-Perú), A18040271 (VRI-UNMSM-Peru), and AGL2015-66886-R (MINECO, Spain). Peer reviewed 2019-11-18T13:57:10Z 2019-11-18T13:57:10Z 2018 póster de congreso http://purl.org/coar/resource_type/c_6670 2nd International Conference on Food Bioactives and Health (2018) http://hdl.handle.net/10261/194798 http://dx.doi.org/10.13039/501100003329 en #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-66886-R Publisher's version Sí open
institution	CIAL ES
collection	DSpace
country	España
countrycode	ES
component	Bibliográfico
access	En linea
databasecode	dig-cial-es
tag	biblioteca
region	Europa del Sur
libraryname	Biblioteca del CIAL España
language	English
topic	Erythrina edulis Multifunctional peptides Bioavailability Erythrina edulis Multifunctional peptides Bioavailability
spellingShingle	Erythrina edulis Multifunctional peptides Bioavailability Erythrina edulis Multifunctional peptides Bioavailability Intiquilla, Arturo Indiano-Romacho, Pedro Jiménez-Aliaga, Karim Izaguirre, Víctor Zavaleta, Amparo I. Amigo, Lourdes Hernández-Ledesma, Blanca Multifunctionality and bioavailability of peptides derived from Erythrina edulis (pajuro) protein
description	Trabajo presentado a la 2nd International Conference on Food Bioactives and Health, celebrada en Lisboa (Portugal) del 26 al 28 de septiembre de 2018.
author2	Ministerio de Economía y Competitividad (España)
author_facet	Ministerio de Economía y Competitividad (España) Intiquilla, Arturo Indiano-Romacho, Pedro Jiménez-Aliaga, Karim Izaguirre, Víctor Zavaleta, Amparo I. Amigo, Lourdes Hernández-Ledesma, Blanca
format	póster de congreso
topic_facet	Erythrina edulis Multifunctional peptides Bioavailability
author	Intiquilla, Arturo Indiano-Romacho, Pedro Jiménez-Aliaga, Karim Izaguirre, Víctor Zavaleta, Amparo I. Amigo, Lourdes Hernández-Ledesma, Blanca
author_sort	Intiquilla, Arturo
title	Multifunctionality and bioavailability of peptides derived from Erythrina edulis (pajuro) protein
title_short	Multifunctionality and bioavailability of peptides derived from Erythrina edulis (pajuro) protein
title_full	Multifunctionality and bioavailability of peptides derived from Erythrina edulis (pajuro) protein
title_fullStr	Multifunctionality and bioavailability of peptides derived from Erythrina edulis (pajuro) protein
title_full_unstemmed	Multifunctionality and bioavailability of peptides derived from Erythrina edulis (pajuro) protein
title_sort	multifunctionality and bioavailability of peptides derived from erythrina edulis (pajuro) protein
publishDate	2018
url	http://hdl.handle.net/10261/194798 http://dx.doi.org/10.13039/501100003329
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Multifunctionality and bioavailability of peptides derived from Erythrina edulis (pajuro) protein

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