A review of bioactive factors in human breastmilk: A focus on prematurity
Preterm birth is an increasing worldwide problem. Prematurity is the second most common cause of death in children under 5 years of age. It is associated with a higher risk of several pathologies in the perinatal period and adulthood. Maternal milk, a complex fluid with several bioactive factors, is the best option for the newborn. Its dynamic composition is influenced by diverse factors such as maternal age, lactation period, and health status. The aim of the present review is to summarize the current knowledge regarding some bioactive factors present in breastmilk, namely antioxidants, growth factors, adipokines, and cytokines, paying specific attention to prematurity. The revised literature reveals that the highest levels of these bioactive factors are found in the colostrum and they decrease along the lactation period; bioactive factors are found in higher levels in preterm as compared to full-term milk, they are lacking in formula milk, and decreased in donated milk. However, there are still some gaps and inconclusive data, and further research in this field is needed. Given the fact that many preterm mothers are unable to complete breastfeeding, new information could be important to develop infant supplements that best match preterm human milk.
Main Authors: | Gila-Diaz, Andrea, Arribas, Silvia M., Algara, Alba, Martín-Cabrejas, María A., López de Pablo, Ángel L., Saenz de Pipaón, Miguel, Ramiro-Cortijo, David |
---|---|
Other Authors: | Agencia Estatal de Investigación (España) |
Format: | artículo biblioteca |
Language: | English |
Published: |
Multidisciplinary Digital Publishing Institute
2019
|
Subjects: | Adipokines, Antioxidants, Breastfeeding, Cytokines, Growth factors, |
Online Access: | http://hdl.handle.net/10261/193006 http://dx.doi.org/10.13039/501100000780 http://dx.doi.org/10.13039/501100003329 http://dx.doi.org/10.13039/501100011033 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Breast milk immune composition varies during the transition stage of lactation: characterization of immunotypes in the MAMI cohort
by: Rio-Aige, Karla, et al.
Published: (2023-11-23) -
Adipokines, cortisol and cytokine alterations in recent onset anorexia nervosa. A case-control study
by: Elegido, Ana, et al.
Published: (2019) -
Longitudinal study of cytokine expression, lipid profile and neuronal growth factors in human breast milk from term and preterm deliveries
by: Collado, María Carmen, et al.
Published: (2015-10-19) -
Impact of anorexia nervosa on immunological biomarkers
by: Nova, Esther, et al.
Published: (2017) -
Secretome analysis of rat adipose tissues shows location-specific roles for each depot type
by: Roca-Rivada, Arturo, et al.
Published: (2011-06-10)