The Diamond Sting server.

Diamond STING is a new version of the STING suite of programs for a comprehensive analysis of a relationship between protein sequence, structure, function and stability. We have added a number of new functionalities by both providing more structure parameters to the STING Database and by improving/ expanding the Interface for enhanced data handling. The integration among the STING components has also been Improved. A new key feature is the ability of the STING server to handle local files containing protein structures (either modeled or not yet deposited to the Protein Data Bank) so that they can be used by the principal STING components: JavaProtein Dossier (JPD) and STING Report. The current capabilities of the new STING version and a couple of biologically relevant applications are described here. We have provided an example where Diamond STING identifies the active site amino acids and folding essential amino acids (both previously determined by experiments) by filtering out all but those residues by selecting the numerical values/ranges for a set of corresponding parameters. This is the fundamental step toward a more interesting endeavor-the prediction of such residues.

Bibliographic Details

Main Authors:	NESHICH, G., BORRO, L. C., HIGA, R. H., KUSER, P. R., YAMAGISHI, M. E. B., FRANCO, E. H., KRAUCHENCO, J. N., FILETO, R., RIBEIRO, A. A., BEZERRA, G. B. P., VELLUDO, T. M., JIMENEZ, T. S., FURUKAWA, N., TESHIMA, H., KITAJIMA, K., BAVA, A., SARAI, A., TOGAWA, R. C., MANCINI, A. L.
Other Authors:	GORAN NESHICH, CNPTIA; LUIZ C. BORRO; ROBERTO HIROSHI HIGA, CNPTIA; PAULA REGINA KUSER, CNPTIA; MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA; EDUARDO H. FRANCO; JOÃO N. KRAUCHENCO; RENATO FILETO; ANDRÉ A. RIBEIRO; GEORGE B. P. BEZERRA; THIAGO M. VELLUDO; THOMÁS S. JIMENEZ; NOBORU FURUKAWA, Department of Bioscience and Bioinformatics/Kyushu Institute of Technology (KIT); HIROFUMI TESHIMA, KIT; KOJI KITAJIMA, KIT; ABDULLA BAVA, KIT; AKINORI SARAI, KIT; ROBERTO COITI TOGAWA, CENARGEN; ADAUTO LUIZ MANCINI, CNPTIA.
Format:	Artigo de periódico biblioteca
Language:	English eng
Published:	2005-08-04
Subjects:	Estrutura de proteína, Diamond STING, STING, JavaProtein Dossier., Proteina., Protein structure.,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/9085
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