Immunomodulatory and anticancer effects of Fridericia chica extract-loaded nanocapsules in myeloid leukemia.

Nanocapsules provide selective delivery and increase the bioavailability of bioactive compounds. In this study, we examined the anticancer and immunomodulatory potential of Fridericia chica (crajiru) extract encapsulated in nanocapsules targeting myeloid leukemias. Nanocapsules containing crajiru (nanocapsules-CRJ) were prepared via interfacial polymer deposition and solvent displacement. Size and polydispersity were measured by dynamic light scattering. Biological assays were performed on leukemia cell lines HL60 and K562 and on non-cancerous Vero cells and human PBMC. The anticancer activity was evaluated using cytotoxicity and clonogenic assays, while the immunomodulatory activity was evaluated by measuring the levels of pro- and anti-inflammatory cytokines in PBMC supernatants treated with concentrations of nanocapsules-CRJ.

Bibliographic Details

Main Authors:	GOMES, A. de F., BATALHA, A. D. de S. J., ALVES, C. E. de C., AZEVEDO, R. G. de, AMADO, J. R. R., SOUZA, T. P. de, KOOLEN, H. H. F., SILVA, F. M. A. da, CHAVES, F. C. M., FLORENTINO NETO, S., BOECHAT, A. L., PONTES, G. S.
Other Authors:	ALICE DE FREITAS GOMES, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; ADRIANE DÂMARES DE SOUZA JORGE BATALHA, UNIVERSIDADE FEDERAL DO AMAZONAS; CARLOS EDUARDO DE CASTRO ALVES, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; RENATA GALVÃO DE AZEVEDO, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; JESUS RAFAEL RODRIGUEZ AMADO, FEDERAL UNIVERSITY OF GRANDE DOURADOS; TATIANE PEREIRA DE SOUZA, UNIVERSIDADE FEDERAL DO AMAZONAS; HECTOR HENRIQUE FERREIRA KOOLEN, UNIVERSIDADE DO ESTADO DO AMAZONAS; FELIPE MOURA ARAÚJO DA SILVA, UNIVERSIDADE FEDERAL DO AMAZONAS; FRANCISCO CELIO MAIA CHAVES, CPAA; SERAFIM FLORENTINO NETO, FEDERAL UNIVERSITY OF GRANDE DOURADOS; ANTÔNIO LUIZ BOECHAT, UNIVERSIDADE FEDERAL DO AMAZONAS; GEMILSON SOARES PONTES, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA.
Format:	Artigo de periódico biblioteca
Language:	eng
Published:	2024-07-15
Subjects:	Fridericia chica, Myeloid leukemias, Arrabidaea, Nanocapsules, Cytotoxicity, Immunomodulation,
Online Access:	http://www.alice.cnptia.embrapa.br/alice/handle/doc/1165782 https://doi.org/10.3390/pharmaceutics16060828
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