Chiral Liquid Chromatography [electronic resource] /

While working as a chromatographer in the pharmaceutical industry, it became apparent to the editor that there was a pressing need for a comprehensive reference text for analysts working on the resolution of enantiomers by liquid chromatography (LC). This need arises from the fact that, whereas previously it was very difficult to determine enantiomers by direct means, there is now a wide choice of direct LC methods. At the same time, regulatory authorities have been changing their attitudes towards the administration of pharmaceuticals as racemates, partly because it is now possible to study the individual enantiomers. Clearly this abundance of new information needs to be rationalized. More importantly, the chiral LC systems which are commercially available or readily accessible to the practising chromatographer needed to be reviewed and, to a much greater extent than in existing reviews or books, discussed in terms of their practical application. Accordingly this book is very much orientated towards the practical aspects of these commercially available and readily accessible chiral LC systems. To this end, it is written for practising chromatographers by a team of practising, experienced chromatographers who have spent many years tackling the problems presented by resolving enantiomers by LC. The practical aspects of common chiral LC systems cannot be fully understood if discussed in isolation.

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Main Authors: Lough, W. J. editor., SpringerLink (Online service)
Format: Texto biblioteca
Language:eng
Published: Dordrecht : Springer Netherlands, 1989
Subjects:Chemistry., Science., Chromatography., Science, general.,
Online Access:http://dx.doi.org/10.1007/978-94-009-0861-1
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spelling KOHA-OAI-TEST:2230302018-07-31T00:01:53ZChiral Liquid Chromatography [electronic resource] / Lough, W. J. editor. SpringerLink (Online service) textDordrecht : Springer Netherlands,1989.engWhile working as a chromatographer in the pharmaceutical industry, it became apparent to the editor that there was a pressing need for a comprehensive reference text for analysts working on the resolution of enantiomers by liquid chromatography (LC). This need arises from the fact that, whereas previously it was very difficult to determine enantiomers by direct means, there is now a wide choice of direct LC methods. At the same time, regulatory authorities have been changing their attitudes towards the administration of pharmaceuticals as racemates, partly because it is now possible to study the individual enantiomers. Clearly this abundance of new information needs to be rationalized. More importantly, the chiral LC systems which are commercially available or readily accessible to the practising chromatographer needed to be reviewed and, to a much greater extent than in existing reviews or books, discussed in terms of their practical application. Accordingly this book is very much orientated towards the practical aspects of these commercially available and readily accessible chiral LC systems. To this end, it is written for practising chromatographers by a team of practising, experienced chromatographers who have spent many years tackling the problems presented by resolving enantiomers by LC. The practical aspects of common chiral LC systems cannot be fully understood if discussed in isolation.1 Introduction -- 1 Molecular asymmetry -- 2 The importance of enantiomer separations -- 3 Chiral liquid chromatography: past and present -- 2 Chiral Derivatization -- 4 Chiral derivatization -- 3 Direct Chiral Resolution -- 5 Chiral ligand exchange chromatography -- 6 Synthetic multiple-interaction chiral bonded phases -- 7 Immobilized proteins as HPLC chiral stationary phases -- 8 Cyclodextrin inclusion complexation -- 9 Binding to cellulose derivatives -- 10 Binding to synthetic polymers -- 11 Ion-pairing -- 12 Other direct chiral resolution methods -- 4 Strategy for Development of LC Enantiomeric Determination Methods -- 13 Consideration of other techniques -- 14 Choice of chiral LC systems -- 15 Optimization -- 5 Future Trends and Requirements -- 16 Future trends and requirements.While working as a chromatographer in the pharmaceutical industry, it became apparent to the editor that there was a pressing need for a comprehensive reference text for analysts working on the resolution of enantiomers by liquid chromatography (LC). This need arises from the fact that, whereas previously it was very difficult to determine enantiomers by direct means, there is now a wide choice of direct LC methods. At the same time, regulatory authorities have been changing their attitudes towards the administration of pharmaceuticals as racemates, partly because it is now possible to study the individual enantiomers. Clearly this abundance of new information needs to be rationalized. More importantly, the chiral LC systems which are commercially available or readily accessible to the practising chromatographer needed to be reviewed and, to a much greater extent than in existing reviews or books, discussed in terms of their practical application. Accordingly this book is very much orientated towards the practical aspects of these commercially available and readily accessible chiral LC systems. To this end, it is written for practising chromatographers by a team of practising, experienced chromatographers who have spent many years tackling the problems presented by resolving enantiomers by LC. The practical aspects of common chiral LC systems cannot be fully understood if discussed in isolation.Chemistry.Science.Chromatography.Chemistry.Chromatography.Science, general.Springer eBookshttp://dx.doi.org/10.1007/978-94-009-0861-1URN:ISBN:9789400908611
institution COLPOS
collection Koha
country México
countrycode MX
component Bibliográfico
access En linea
En linea
databasecode cat-colpos
tag biblioteca
region America del Norte
libraryname Departamento de documentación y biblioteca de COLPOS
language eng
topic Chemistry.
Science.
Chromatography.
Chemistry.
Chromatography.
Science, general.
Chemistry.
Science.
Chromatography.
Chemistry.
Chromatography.
Science, general.
spellingShingle Chemistry.
Science.
Chromatography.
Chemistry.
Chromatography.
Science, general.
Chemistry.
Science.
Chromatography.
Chemistry.
Chromatography.
Science, general.
Lough, W. J. editor.
SpringerLink (Online service)
Chiral Liquid Chromatography [electronic resource] /
description While working as a chromatographer in the pharmaceutical industry, it became apparent to the editor that there was a pressing need for a comprehensive reference text for analysts working on the resolution of enantiomers by liquid chromatography (LC). This need arises from the fact that, whereas previously it was very difficult to determine enantiomers by direct means, there is now a wide choice of direct LC methods. At the same time, regulatory authorities have been changing their attitudes towards the administration of pharmaceuticals as racemates, partly because it is now possible to study the individual enantiomers. Clearly this abundance of new information needs to be rationalized. More importantly, the chiral LC systems which are commercially available or readily accessible to the practising chromatographer needed to be reviewed and, to a much greater extent than in existing reviews or books, discussed in terms of their practical application. Accordingly this book is very much orientated towards the practical aspects of these commercially available and readily accessible chiral LC systems. To this end, it is written for practising chromatographers by a team of practising, experienced chromatographers who have spent many years tackling the problems presented by resolving enantiomers by LC. The practical aspects of common chiral LC systems cannot be fully understood if discussed in isolation.
format Texto
topic_facet Chemistry.
Science.
Chromatography.
Chemistry.
Chromatography.
Science, general.
author Lough, W. J. editor.
SpringerLink (Online service)
author_facet Lough, W. J. editor.
SpringerLink (Online service)
author_sort Lough, W. J. editor.
title Chiral Liquid Chromatography [electronic resource] /
title_short Chiral Liquid Chromatography [electronic resource] /
title_full Chiral Liquid Chromatography [electronic resource] /
title_fullStr Chiral Liquid Chromatography [electronic resource] /
title_full_unstemmed Chiral Liquid Chromatography [electronic resource] /
title_sort chiral liquid chromatography [electronic resource] /
publisher Dordrecht : Springer Netherlands,
publishDate 1989
url http://dx.doi.org/10.1007/978-94-009-0861-1
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